Ototoxicity of aminoglycoside drugs in tuberculosis treatment
The possible ototoxic effect of kanamycin, streptomycin and a standard anti-TB drug combination, used in the treatment of 92 TB patients (7-71 years old), was examined by measuring the highest audible electric bone conduction frequency before and after treatment, using an audimax 500 audiometer. At...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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AOSIS
1996-12-01
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| Series: | South African Journal of Communication Disorders |
| Subjects: | |
| Online Access: | https://sajcd.org.za/index.php/sajcd/article/view/233 |
| _version_ | 1819116130739945472 |
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| author | G. R. Voogt H. S. Schoeman |
| author_facet | G. R. Voogt H. S. Schoeman |
| author_sort | G. R. Voogt |
| collection | DOAJ |
| description | The possible ototoxic effect of kanamycin, streptomycin and a standard anti-TB drug combination, used in the treatment of 92 TB patients (7-71 years old), was examined by measuring the highest audible electric bone conduction frequency before and after treatment, using an audimax 500 audiometer. At the so-called "safe" levels of drug administration it was found that kanamycin was markedly ototoxic effect. Furthermore, it was found that none of these drugs were gender specific. Lastly, the possible effects of ageing on highest audible bone conduction frequency is discussed. |
| first_indexed | 2024-12-22T05:12:12Z |
| format | Article |
| id | doaj.art-db867c7f491e4347a24510a53a326239 |
| institution | Directory Open Access Journal |
| issn | 0379-8046 2225-4765 |
| language | English |
| last_indexed | 2024-12-22T05:12:12Z |
| publishDate | 1996-12-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Journal of Communication Disorders |
| spelling | doaj.art-db867c7f491e4347a24510a53a3262392022-12-21T18:37:58ZengAOSISSouth African Journal of Communication Disorders0379-80462225-47651996-12-0143110.4102/sajcd.v43i1.233136Ototoxicity of aminoglycoside drugs in tuberculosis treatmentG. R. Voogt0H. S. Schoeman1Department of Otorhinolaryngology, Medical University of Southern AfricaDepartment of Mathematics and Statistics, Medical University of Southern AfricaThe possible ototoxic effect of kanamycin, streptomycin and a standard anti-TB drug combination, used in the treatment of 92 TB patients (7-71 years old), was examined by measuring the highest audible electric bone conduction frequency before and after treatment, using an audimax 500 audiometer. At the so-called "safe" levels of drug administration it was found that kanamycin was markedly ototoxic effect. Furthermore, it was found that none of these drugs were gender specific. Lastly, the possible effects of ageing on highest audible bone conduction frequency is discussed.https://sajcd.org.za/index.php/sajcd/article/view/233kanamycinstrepomycintuberculosishigh frequency hearing |
| spellingShingle | G. R. Voogt H. S. Schoeman Ototoxicity of aminoglycoside drugs in tuberculosis treatment South African Journal of Communication Disorders kanamycin strepomycin tuberculosis high frequency hearing |
| title | Ototoxicity of aminoglycoside drugs in tuberculosis treatment |
| title_full | Ototoxicity of aminoglycoside drugs in tuberculosis treatment |
| title_fullStr | Ototoxicity of aminoglycoside drugs in tuberculosis treatment |
| title_full_unstemmed | Ototoxicity of aminoglycoside drugs in tuberculosis treatment |
| title_short | Ototoxicity of aminoglycoside drugs in tuberculosis treatment |
| title_sort | ototoxicity of aminoglycoside drugs in tuberculosis treatment |
| topic | kanamycin strepomycin tuberculosis high frequency hearing |
| url | https://sajcd.org.za/index.php/sajcd/article/view/233 |
| work_keys_str_mv | AT grvoogt ototoxicityofaminoglycosidedrugsintuberculosistreatment AT hsschoeman ototoxicityofaminoglycosidedrugsintuberculosistreatment |