BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis

BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis

<b>Introduction:</b> Neuroblastoma (NB) is one of the most common extracranial solid malignant tumors in children. The 5-year survival rate of high-risk or refractory NB is less than 50%. Therefore, developing new effective therapeutics for NB remains an urgent challenge. <b>Materi...

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Bibliographic Details
Main Authors: Liming Jin, Tao Mi, Xin Wu, Zhang Wang, Zhaoxia Zhang, Jiayan Liu, Zhaoying Wang, Jinkui Wang, Mujie Li, Chunnian Ren, Peng Guo, Dawei He
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
neuroblastoma
BI-D1870
RSK
mTORC1
G2/M arrest
Online Access:https://www.mdpi.com/2072-6694/15/7/2023

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