BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells

BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells

P2X7 receptor (P2RX7) is expressed strongly by most human cancers, including neuroblastoma, where high levels of P2RX7 are correlated with a poor prognosis for patients. Tonic activation of P2X7 receptor favors cell metabolism and angiogenesis, thereby promoting cancer cell proliferation, immunosupp...

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Bibliografski detalji
Glavni autori: María Benito-León, Juan Carlos Gil-Redondo, Raquel Perez-Sen, Esmerilda G. Delicado, Felipe Ortega, Rosa Gomez-Villafuertes
Format: Članak
Jezik:English
Izdano: Frontiers Media S.A. 2022-12-01
Serija:Frontiers in Cell and Developmental Biology
Teme:
P2X7 receptor
neuroblastoma
DUSP1
p38 phosphorylation
Sp1 transcription factor
phosphatase inhibitor
Online pristup:https://www.frontiersin.org/articles/10.3389/fcell.2022.1049566/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.1049566/full

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