BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells

BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells

P2X7 receptor (P2RX7) is expressed strongly by most human cancers, including neuroblastoma, where high levels of P2RX7 are correlated with a poor prognosis for patients. Tonic activation of P2X7 receptor favors cell metabolism and angiogenesis, thereby promoting cancer cell proliferation, immunosupp...

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Detalhes bibliográficos
Principais autores: María Benito-León, Juan Carlos Gil-Redondo, Raquel Perez-Sen, Esmerilda G. Delicado, Felipe Ortega, Rosa Gomez-Villafuertes
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2022-12-01
coleção:Frontiers in Cell and Developmental Biology
Assuntos:
P2X7 receptor
neuroblastoma
DUSP1
p38 phosphorylation
Sp1 transcription factor
phosphatase inhibitor
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2022.1049566/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.1049566/full

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