BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells
P2X7 receptor (P2RX7) is expressed strongly by most human cancers, including neuroblastoma, where high levels of P2RX7 are correlated with a poor prognosis for patients. Tonic activation of P2X7 receptor favors cell metabolism and angiogenesis, thereby promoting cancer cell proliferation, immunosupp...
| Главные авторы: | , , , , , |
|---|---|
| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Frontiers Media S.A.
2022-12-01
|
| Серии: | Frontiers in Cell and Developmental Biology |
| Предметы: | |
| Online-ссылка: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1049566/full |