Biofabrication of tissue engineering vascular systems
Cardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can serve as grafts for CVD treatment and be used as in vitro model systems to examine the role of various gen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2021-06-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/5.0039628 |
| _version_ | 1818737874804146176 |
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| author | Qiao Zhang Èlia Bosch-Rué Román A. Pérez George A. Truskey |
| author_facet | Qiao Zhang Èlia Bosch-Rué Román A. Pérez George A. Truskey |
| author_sort | Qiao Zhang |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can serve as grafts for CVD treatment and be used as in vitro model systems to examine the role of various genetic factors during the CVD progressions. Current focus in the field is to fabricate TEVS that more closely resembles the mechanical properties and extracellular matrix environment of native vessels, which depends heavily on the advance in biofabrication techniques and discovery of novel biomaterials. In this review, we outline the mechanical and biological design requirements of TEVS and explore the history and recent advances in biofabrication methods and biomaterials for tissue engineered blood vessels and microvascular systems with special focus on in vitro applications. In vitro applications of TEVS for disease modeling are discussed. |
| first_indexed | 2024-12-18T00:59:59Z |
| format | Article |
| id | doaj.art-db8c5e79ce794a269e2cd13de183f476 |
| institution | Directory Open Access Journal |
| issn | 2473-2877 |
| language | English |
| last_indexed | 2024-12-18T00:59:59Z |
| publishDate | 2021-06-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj.art-db8c5e79ce794a269e2cd13de183f4762022-12-21T21:26:25ZengAIP Publishing LLCAPL Bioengineering2473-28772021-06-0152021507021507-1810.1063/5.0039628Biofabrication of tissue engineering vascular systemsQiao Zhang0Èlia Bosch-Rué1Román A. Pérez2George A. Truskey3 Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA Bioengineering Institute of Technology (BIT), Universitat Internacional de Catalunya (UIC), Sant Cugat del Vallès 08195, Spain Bioengineering Institute of Technology (BIT), Universitat Internacional de Catalunya (UIC), Sant Cugat del Vallès 08195, Spain Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USACardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can serve as grafts for CVD treatment and be used as in vitro model systems to examine the role of various genetic factors during the CVD progressions. Current focus in the field is to fabricate TEVS that more closely resembles the mechanical properties and extracellular matrix environment of native vessels, which depends heavily on the advance in biofabrication techniques and discovery of novel biomaterials. In this review, we outline the mechanical and biological design requirements of TEVS and explore the history and recent advances in biofabrication methods and biomaterials for tissue engineered blood vessels and microvascular systems with special focus on in vitro applications. In vitro applications of TEVS for disease modeling are discussed.http://dx.doi.org/10.1063/5.0039628 |
| spellingShingle | Qiao Zhang Èlia Bosch-Rué Román A. Pérez George A. Truskey Biofabrication of tissue engineering vascular systems APL Bioengineering |
| title | Biofabrication of tissue engineering vascular systems |
| title_full | Biofabrication of tissue engineering vascular systems |
| title_fullStr | Biofabrication of tissue engineering vascular systems |
| title_full_unstemmed | Biofabrication of tissue engineering vascular systems |
| title_short | Biofabrication of tissue engineering vascular systems |
| title_sort | biofabrication of tissue engineering vascular systems |
| url | http://dx.doi.org/10.1063/5.0039628 |
| work_keys_str_mv | AT qiaozhang biofabricationoftissueengineeringvascularsystems AT eliaboschrue biofabricationoftissueengineeringvascularsystems AT romanaperez biofabricationoftissueengineeringvascularsystems AT georgeatruskey biofabricationoftissueengineeringvascularsystems |