Fasting inhibits excitatory synaptic input on paraventricular oxytocin neurons via neuropeptide Y and Y1 receptor, inducing rebound hyperphagia, and weight gain

Fasting inhibits excitatory synaptic input on paraventricular oxytocin neurons via neuropeptide Y and Y1 receptor, inducing rebound hyperphagia, and weight gain

Fasting with varying intensities is used to treat obesity-related diseases. Re-feeding after fasting exhibits hyperphagia and often rebound weight gain. However, the mechanisms underlying the hyperphagia and rebound remain elusive. Here we show that 24 h food restriction (24 h FR) and milder 50% FR,...

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Bibliographic Details
Main Authors: Lei Wang, Shigetomo Suyama, Samantha A. Lee, Yoichi Ueta, Yutaka Seino, Geoffrey W. G. Sharp, Toshihiko Yada
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Nutrition
Subjects:
food restriction
neuropeptide Y
Y1 receptor
paraventricular nucleus
oxytocin
synaptic plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.994827/full

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