CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)
The article presents the results of the I phase of clinical trials of a vaccine preparationfor prevention of Flexner dysentery on the basis of modified Shigella flexneri lipopolysaccharide on the limited contingent of adult volunteers (26 persons). Studying general and local post-inoculative reactio...
| Prif Awduron: | , |
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| Fformat: | Erthygl |
| Iaith: | Russian |
| Cyhoeddwyd: |
Scientific Сentre for Family Health and Human Reproduction Problems
2014-07-01
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| Cyfres: | Acta Biomedica Scientifica |
| Pynciau: | |
| Mynediad Ar-lein: | https://www.actabiomedica.ru/jour/article/view/1797 |
| Crynodeb: | The article presents the results of the I phase of clinical trials of a vaccine preparationfor prevention of Flexner dysentery on the basis of modified Shigella flexneri lipopolysaccharide on the limited contingent of adult volunteers (26 persons). Studying general and local post-inoculative reactions showed good acceptability and low reactogenicity of candidate vaccine "FLEXVAC®" in the doses from 25 to 100 gg. In the majority ofvolunteers immunized by the candidate vaccine "FLEXVAC®" we registered 4 and more times seroconversion of IgG and IgA classes antibodies playing basic role in the formation of adaptive anti-shigella immune response. |
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| ISSN: | 2541-9420 2587-9596 |