The benefits of clustering in TNF receptor superfamily signaling
The tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. This review paper synthesizes key findings from recent stu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1225704/full |
| _version_ | 1797741476292067328 |
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| author | Éva S. Vanamee Denise L. Faustman Denise L. Faustman |
| author_facet | Éva S. Vanamee Denise L. Faustman Denise L. Faustman |
| author_sort | Éva S. Vanamee |
| collection | DOAJ |
| description | The tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. This review paper synthesizes key findings from recent studies, highlighting the importance of clustering in TNF receptor superfamily signaling. We discuss the underlying molecular mechanisms of signaling, the functional consequences of receptor clustering, and potential therapeutic implications of targeting surface structures of receptor complexes. |
| first_indexed | 2024-03-12T14:27:47Z |
| format | Article |
| id | doaj.art-db928060f7954cf1b51a17b2fa36d1b2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T14:27:47Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-db928060f7954cf1b51a17b2fa36d1b22023-08-18T04:16:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-08-011410.3389/fimmu.2023.12257041225704The benefits of clustering in TNF receptor superfamily signalingÉva S. Vanamee0Denise L. Faustman1Denise L. Faustman2Immunobiology Department, Massachusetts General Hospital, Boston, MA, United StatesImmunobiology Department, Massachusetts General Hospital, Boston, MA, United StatesHarvard Medical School, Boston, MA, United StatesThe tumor necrosis factor (TNF) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. This review paper synthesizes key findings from recent studies, highlighting the importance of clustering in TNF receptor superfamily signaling. We discuss the underlying molecular mechanisms of signaling, the functional consequences of receptor clustering, and potential therapeutic implications of targeting surface structures of receptor complexes.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1225704/fullTNF receptor superfamily (TNFRSF)TNF signalingreceptor clusteringTNFR agonism and antagonismsignal amplification |
| spellingShingle | Éva S. Vanamee Denise L. Faustman Denise L. Faustman The benefits of clustering in TNF receptor superfamily signaling Frontiers in Immunology TNF receptor superfamily (TNFRSF) TNF signaling receptor clustering TNFR agonism and antagonism signal amplification |
| title | The benefits of clustering in TNF receptor superfamily signaling |
| title_full | The benefits of clustering in TNF receptor superfamily signaling |
| title_fullStr | The benefits of clustering in TNF receptor superfamily signaling |
| title_full_unstemmed | The benefits of clustering in TNF receptor superfamily signaling |
| title_short | The benefits of clustering in TNF receptor superfamily signaling |
| title_sort | benefits of clustering in tnf receptor superfamily signaling |
| topic | TNF receptor superfamily (TNFRSF) TNF signaling receptor clustering TNFR agonism and antagonism signal amplification |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1225704/full |
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