Ketamine-snorting associated cystitis
Ketamine hydrochloride, commonly used as a pediatric anesthetic agent, is an N-methyl-d-aspartic (NMDA) acid receptor antagonist with rapid onset and short duration of action. It produces a cataleptic-like state where the patient is dissociated from the surrounding environment by direct action on th...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-12-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664611001355 |
| _version_ | 1819027290902757376 |
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| author | Chung-Hsien Chen Ming-Huei Lee Yi-Chang Chen Ming-Fong Lin |
| author_facet | Chung-Hsien Chen Ming-Huei Lee Yi-Chang Chen Ming-Fong Lin |
| author_sort | Chung-Hsien Chen |
| collection | DOAJ |
| description | Ketamine hydrochloride, commonly used as a pediatric anesthetic agent, is an N-methyl-d-aspartic (NMDA) acid receptor antagonist with rapid onset and short duration of action. It produces a cataleptic-like state where the patient is dissociated from the surrounding environment by direct action on the cortex and limbic system. It has emerged as an increasingly popular choice among young drug users, especially within dance club venues. Cases of bladder dysfunction among recreational ketamine users were reported since Shahani et al first reported nine cases of ketamine-associated ulcerative cystitis in 2007. We report on four patients who had history of ketamine abuse, presenting with dysuria, fluctuating lower urinary tract symptoms (LUTS), lower abdominal or perineal pain, and impaired functional bladder capacities. Urinalysis showed pyuria and microhematuria. Urine culture was sterile. Bladder ulceration with severe diffuse hemorrhage and low bladder capacity were noted under anesthetized cystoscopic examination. Transurethral bladder mucosa biopsy was consistent with chronic cystitis. Cessation of ketamine abuse was the milestone of treatment, followed by the administration of mucosal protective agents, such as pentosan polysulphate or hyaluronic acid. Suprapubic pain was improved in three patients during follow-up. However, the outcome of treatment depends on the severity of the disease process, similar to that of interstitial cystitis (IC). |
| first_indexed | 2024-12-21T05:40:08Z |
| format | Article |
| id | doaj.art-db93cd1ba4934990b0fb5e86f4d4f921 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-21T05:40:08Z |
| publishDate | 2011-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-db93cd1ba4934990b0fb5e86f4d4f9212022-12-21T19:14:17ZengElsevierJournal of the Formosan Medical Association0929-66462011-12-011101278779110.1016/j.jfma.2011.11.010Ketamine-snorting associated cystitisChung-Hsien Chen0Ming-Huei Lee1Yi-Chang Chen2Ming-Fong Lin3Department of Urology, Taichung Hospital, Department of Health, Executive Yuan, Taichung, Taiwan, ROCDepartment of Urology, Taichung Hospital, Department of Health, Executive Yuan, Taichung, Taiwan, ROCDepartment of Urology, Taichung Hospital, Department of Health, Executive Yuan, Taichung, Taiwan, ROCDepartment of Urology, Taichung Hospital, Department of Health, Executive Yuan, Taichung, Taiwan, ROCKetamine hydrochloride, commonly used as a pediatric anesthetic agent, is an N-methyl-d-aspartic (NMDA) acid receptor antagonist with rapid onset and short duration of action. It produces a cataleptic-like state where the patient is dissociated from the surrounding environment by direct action on the cortex and limbic system. It has emerged as an increasingly popular choice among young drug users, especially within dance club venues. Cases of bladder dysfunction among recreational ketamine users were reported since Shahani et al first reported nine cases of ketamine-associated ulcerative cystitis in 2007. We report on four patients who had history of ketamine abuse, presenting with dysuria, fluctuating lower urinary tract symptoms (LUTS), lower abdominal or perineal pain, and impaired functional bladder capacities. Urinalysis showed pyuria and microhematuria. Urine culture was sterile. Bladder ulceration with severe diffuse hemorrhage and low bladder capacity were noted under anesthetized cystoscopic examination. Transurethral bladder mucosa biopsy was consistent with chronic cystitis. Cessation of ketamine abuse was the milestone of treatment, followed by the administration of mucosal protective agents, such as pentosan polysulphate or hyaluronic acid. Suprapubic pain was improved in three patients during follow-up. However, the outcome of treatment depends on the severity of the disease process, similar to that of interstitial cystitis (IC).http://www.sciencedirect.com/science/article/pii/S0929664611001355cystitisinterstitial cystitisketamine |
| spellingShingle | Chung-Hsien Chen Ming-Huei Lee Yi-Chang Chen Ming-Fong Lin Ketamine-snorting associated cystitis Journal of the Formosan Medical Association cystitis interstitial cystitis ketamine |
| title | Ketamine-snorting associated cystitis |
| title_full | Ketamine-snorting associated cystitis |
| title_fullStr | Ketamine-snorting associated cystitis |
| title_full_unstemmed | Ketamine-snorting associated cystitis |
| title_short | Ketamine-snorting associated cystitis |
| title_sort | ketamine snorting associated cystitis |
| topic | cystitis interstitial cystitis ketamine |
| url | http://www.sciencedirect.com/science/article/pii/S0929664611001355 |
| work_keys_str_mv | AT chunghsienchen ketaminesnortingassociatedcystitis AT minghueilee ketaminesnortingassociatedcystitis AT yichangchen ketaminesnortingassociatedcystitis AT mingfonglin ketaminesnortingassociatedcystitis |