Holotoxin disassembly by protein disulfide isomerase is less efficient for Escherichia coli heat-labile enterotoxin than cholera toxin
Abstract Cholera toxin (CT) and Escherichia coli heat-labile enterotoxin (LT) are structurally similar AB5-type protein toxins. They move from the cell surface to the endoplasmic reticulum where the A1 catalytic subunit is separated from its holotoxin by protein disulfide isomerase (PDI), thus allow...
| Main Authors: | , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
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Nature Portfolio
2022-01-01
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| 丛编: | Scientific Reports |
| 在线阅读: | https://doi.org/10.1038/s41598-021-03939-9 |