Cilostazol Stimulates Angiogenesis and Accelerates Fracture Healing in Aged Male and Female Mice by Increasing the Expression of PI3K and RUNX2

Cilostazol Stimulates Angiogenesis and Accelerates Fracture Healing in Aged Male and Female Mice by Increasing the Expression of PI3K and RUNX2

Fracture healing in the aged is associated with a reduced healing capacity, which often results in delayed healing or non-union formation. Many factors may contribute to this deterioration of bone regeneration, including a reduced ‘angiogenic trauma response’. The phosphodiesterase-3 (PDE-3) inhibit...

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Bibliographic Details
Main Authors: Maximilian M. Menger, Maximilian Emmerich, Claudia Scheuer, Sandra Hans, Sabrina Ehnert, Andreas K. Nüssler, Steven C. Herath, Konrad Steinestel, Michael D. Menger, Tina Histing, Matthias W. Laschke
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
mice
cilostazol
aging
fracture healing
angiogenesis
RUNX2
Online Access:https://www.mdpi.com/1422-0067/25/2/755

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