Perspectives on the Use of Mesenchymal Stem Cells in Vascularized Composite Allotransplantation
Reconstructive transplantation has emerged as clinical reality over the past decade. Utilizing standard immunosuppressive drugs has proven feasible in face and hand transplantation to achieve long-term graft acceptance. As vascularized composite tissue allotransplantation is not a life-saving proced...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-07-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00175/full |
| _version_ | 1818513522327289856 |
|---|---|
| author | Jan A. Plock Jan A. Plock Jonas T. Schnider Mario G. Solari Xin Xiao eZheng Xin Xiao eZheng Vijay S. Gorantla |
| author_facet | Jan A. Plock Jan A. Plock Jonas T. Schnider Mario G. Solari Xin Xiao eZheng Xin Xiao eZheng Vijay S. Gorantla |
| author_sort | Jan A. Plock |
| collection | DOAJ |
| description | Reconstructive transplantation has emerged as clinical reality over the past decade. Utilizing standard immunosuppressive drugs has proven feasible in face and hand transplantation to achieve long-term graft acceptance. As vascularized composite tissue allotransplantation is not a life-saving procedure compared to solid organ transplantation alternative protocols with less long-term side effects are even more desirable. Allograft tolerance is the holy grail of many cell-based concepts and recent data in the field is most promising. Immunomodulation with mesenchymal stem cells from bone marrow and adipose tissue has shown high potential in this respect. This article is aiming at giving an overview on the experimental studies available, the scientific background and clinical applications. Furthermore we address essential questions prior to the use of mesenchymal stem cells in reconstructive allotransplantation. |
| first_indexed | 2024-12-11T00:02:38Z |
| format | Article |
| id | doaj.art-db96b51cd7264235ab8628a762497cab |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T00:02:38Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-db96b51cd7264235ab8628a762497cab2022-12-22T01:28:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-07-01410.3389/fimmu.2013.0017555534Perspectives on the Use of Mesenchymal Stem Cells in Vascularized Composite AllotransplantationJan A. Plock0Jan A. Plock1Jonas T. Schnider2Mario G. Solari3Xin Xiao eZheng4Xin Xiao eZheng5Vijay S. Gorantla6University of ZurichUPMC, University of PIttsburghUPMC, University of PIttsburghUPMC, University of PIttsburghUPMC, University of PIttsburghTongji UniversityUPMC, University of PIttsburghReconstructive transplantation has emerged as clinical reality over the past decade. Utilizing standard immunosuppressive drugs has proven feasible in face and hand transplantation to achieve long-term graft acceptance. As vascularized composite tissue allotransplantation is not a life-saving procedure compared to solid organ transplantation alternative protocols with less long-term side effects are even more desirable. Allograft tolerance is the holy grail of many cell-based concepts and recent data in the field is most promising. Immunomodulation with mesenchymal stem cells from bone marrow and adipose tissue has shown high potential in this respect. This article is aiming at giving an overview on the experimental studies available, the scientific background and clinical applications. Furthermore we address essential questions prior to the use of mesenchymal stem cells in reconstructive allotransplantation.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00175/fullChimerismImmunomodulationtoleranceadipose stem cellscell based therapyComposite Tissue Allotransplantation |
| spellingShingle | Jan A. Plock Jan A. Plock Jonas T. Schnider Mario G. Solari Xin Xiao eZheng Xin Xiao eZheng Vijay S. Gorantla Perspectives on the Use of Mesenchymal Stem Cells in Vascularized Composite Allotransplantation Frontiers in Immunology Chimerism Immunomodulation tolerance adipose stem cells cell based therapy Composite Tissue Allotransplantation |
| title | Perspectives on the Use of Mesenchymal Stem Cells in Vascularized Composite Allotransplantation |
| title_full | Perspectives on the Use of Mesenchymal Stem Cells in Vascularized Composite Allotransplantation |
| title_fullStr | Perspectives on the Use of Mesenchymal Stem Cells in Vascularized Composite Allotransplantation |
| title_full_unstemmed | Perspectives on the Use of Mesenchymal Stem Cells in Vascularized Composite Allotransplantation |
| title_short | Perspectives on the Use of Mesenchymal Stem Cells in Vascularized Composite Allotransplantation |
| title_sort | perspectives on the use of mesenchymal stem cells in vascularized composite allotransplantation |
| topic | Chimerism Immunomodulation tolerance adipose stem cells cell based therapy Composite Tissue Allotransplantation |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00175/full |
| work_keys_str_mv | AT janaplock perspectivesontheuseofmesenchymalstemcellsinvascularizedcompositeallotransplantation AT janaplock perspectivesontheuseofmesenchymalstemcellsinvascularizedcompositeallotransplantation AT jonastschnider perspectivesontheuseofmesenchymalstemcellsinvascularizedcompositeallotransplantation AT mariogsolari perspectivesontheuseofmesenchymalstemcellsinvascularizedcompositeallotransplantation AT xinxiaoezheng perspectivesontheuseofmesenchymalstemcellsinvascularizedcompositeallotransplantation AT xinxiaoezheng perspectivesontheuseofmesenchymalstemcellsinvascularizedcompositeallotransplantation AT vijaysgorantla perspectivesontheuseofmesenchymalstemcellsinvascularizedcompositeallotransplantation |