The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline
Kamal A Amin1, Mohamed S Hassan2, El-Said T Awad3, Khalid S Hashem11Department of Biochemistry, 2Department of Internal Medicine, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt; 3Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Cairo, EgyptObjecti...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2011-01-01
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| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/the-protective-effects-of-cerium-oxide-nanoparticles-against-hepatic-o-a6072 |
| _version_ | 1818905756316991488 |
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| author | Kamal A Amin Mohamed S Hassan El-Said T Awad et al |
| author_facet | Kamal A Amin Mohamed S Hassan El-Said T Awad et al |
| author_sort | Kamal A Amin |
| collection | DOAJ |
| description | Kamal A Amin1, Mohamed S Hassan2, El-Said T Awad3, Khalid S Hashem11Department of Biochemistry, 2Department of Internal Medicine, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt; 3Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Cairo, EgyptObjective: The objective of the present study was to determine the ability of cerium oxide (CeO2) nanoparticles to protect against monocrotaline (MCT)-induced hepatotoxicity in a rat model.Method: Twenty male Sprague Dawley rats were arbitrarily assigned to four groups: control (received saline), CeO2 (given 0.0001 nmol/kg intraperitoneally [IP]), MCT (given 10 mg/kg body weight IP as a single dose), and MCT + CeO2 (received CeO2 both before and after MCT). Electron microscopic imaging of the rat livers was carried out, and hepatic total glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPX), glutathione S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) enzymatic activities were quantified.Results: Results showed a significant MCT-induced decrease in total hepatic GSH, GPX, GR, and GST normalized to control values with concurrent CeO2 administration. In addition, MCT produced significant increases in hepatic CAT and SOD activities, which also ameliorated with CeO2.Conclusions: These results indicate that CeO2 acts as a putative novel and effective hepatoprotective agent against MCT-induced hepatotoxicity.Keywords: monocrotaline, ceruim oxide nanoparticle, hepatotoxicity, oxidative stress |
| first_indexed | 2024-12-19T21:28:23Z |
| format | Article |
| id | doaj.art-db96bb2b5b8c41c7b4af644485c5c854 |
| institution | Directory Open Access Journal |
| issn | 1176-9114 1178-2013 |
| language | English |
| last_indexed | 2024-12-19T21:28:23Z |
| publishDate | 2011-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-db96bb2b5b8c41c7b4af644485c5c8542022-12-21T20:05:02ZengDove Medical PressInternational Journal of Nanomedicine1176-91141178-20132011-01-012011default143149The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotalineKamal A AminMohamed S HassanEl-Said T Awadet alKamal A Amin1, Mohamed S Hassan2, El-Said T Awad3, Khalid S Hashem11Department of Biochemistry, 2Department of Internal Medicine, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt; 3Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Cairo, EgyptObjective: The objective of the present study was to determine the ability of cerium oxide (CeO2) nanoparticles to protect against monocrotaline (MCT)-induced hepatotoxicity in a rat model.Method: Twenty male Sprague Dawley rats were arbitrarily assigned to four groups: control (received saline), CeO2 (given 0.0001 nmol/kg intraperitoneally [IP]), MCT (given 10 mg/kg body weight IP as a single dose), and MCT + CeO2 (received CeO2 both before and after MCT). Electron microscopic imaging of the rat livers was carried out, and hepatic total glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPX), glutathione S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) enzymatic activities were quantified.Results: Results showed a significant MCT-induced decrease in total hepatic GSH, GPX, GR, and GST normalized to control values with concurrent CeO2 administration. In addition, MCT produced significant increases in hepatic CAT and SOD activities, which also ameliorated with CeO2.Conclusions: These results indicate that CeO2 acts as a putative novel and effective hepatoprotective agent against MCT-induced hepatotoxicity.Keywords: monocrotaline, ceruim oxide nanoparticle, hepatotoxicity, oxidative stresshttp://www.dovepress.com/the-protective-effects-of-cerium-oxide-nanoparticles-against-hepatic-o-a6072 |
| spellingShingle | Kamal A Amin Mohamed S Hassan El-Said T Awad et al The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline International Journal of Nanomedicine |
| title | The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline |
| title_full | The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline |
| title_fullStr | The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline |
| title_full_unstemmed | The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline |
| title_short | The protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline |
| title_sort | protective effects of cerium oxide nanoparticles against hepatic oxidative damage induced by monocrotaline |
| url | http://www.dovepress.com/the-protective-effects-of-cerium-oxide-nanoparticles-against-hepatic-o-a6072 |
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