Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006‐2016)
Abstract Background Bronchoalveolar lavage (BAL) fluid cytology and culture are used to characterize respiratory diseases in dogs. Little is known about disorders associated with increased numbers of lymphocytes in BAL fluid. Objective To evaluate duration of clinical signs and detection of specific...
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| Format: | Article |
| Language: | English |
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Wiley
2019-05-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15489 |
| _version_ | 1818577597762633728 |
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| author | Lynelle R. Johnson William Vernau |
| author_facet | Lynelle R. Johnson William Vernau |
| author_sort | Lynelle R. Johnson |
| collection | DOAJ |
| description | Abstract Background Bronchoalveolar lavage (BAL) fluid cytology and culture are used to characterize respiratory diseases in dogs. Little is known about disorders associated with increased numbers of lymphocytes in BAL fluid. Objective To evaluate duration of clinical signs and detection of specific respiratory diagnoses in dogs with BAL lymphocytosis. Animals One‐hundred four client‐owned dogs evaluated for respiratory signs. Methods Medical records of dogs that had >300 cells/μL and >20% lymphocytes on a differential cell count of BAL fluid between January 1, 2006, and January 1, 2016, were reviewed retrospectively. Cases were evaluated for the duration of clinical signs and respiratory diagnoses, including aspiration injury, infectious or inflammatory respiratory disease, and airway collapse. Results Dogs ranged in age from 0.5 to 16 years (median, 7.9 years) and had a median body weight of 11.4 kg (range, 2.0‐42.7 kg). Eosinophilic lung disease was documented in 13 of 104 dogs (Group 1) and airway neutrophilia associated with infectious or inflammatory disease was found in 59 of 104 dogs (Group 2). Lymphocytosis alone in BAL fluid was described in 32 dogs (Group 3). Duration of cough did not differ among groups, but airway collapse was significantly more common in dogs with solitary lymphocytosis than in those with other types of inflammation. Conclusions and Clinical Importance Lymphocytosis in BAL fluid is common in dogs and, in many cases, likely represents a common response to airway injury, independent of the type or duration of insult. It is unknown whether airway collapse leads to lymphocytosis or if the inflammatory process causes airway collapse. |
| first_indexed | 2024-12-16T06:32:27Z |
| format | Article |
| id | doaj.art-db97d725d8c846c9b09839025f4a5751 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-16T06:32:27Z |
| publishDate | 2019-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-db97d725d8c846c9b09839025f4a57512022-12-21T22:40:51ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762019-05-013331315132110.1111/jvim.15489Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006‐2016)Lynelle R. Johnson0William Vernau1Department of Medicine and Epidemiology University of California School of Veterinary Medicine Davis CaliforniaDepartment of Pathology, Microbiology and Immunology University of California School of Veterinary Medicine Davis CaliforniaAbstract Background Bronchoalveolar lavage (BAL) fluid cytology and culture are used to characterize respiratory diseases in dogs. Little is known about disorders associated with increased numbers of lymphocytes in BAL fluid. Objective To evaluate duration of clinical signs and detection of specific respiratory diagnoses in dogs with BAL lymphocytosis. Animals One‐hundred four client‐owned dogs evaluated for respiratory signs. Methods Medical records of dogs that had >300 cells/μL and >20% lymphocytes on a differential cell count of BAL fluid between January 1, 2006, and January 1, 2016, were reviewed retrospectively. Cases were evaluated for the duration of clinical signs and respiratory diagnoses, including aspiration injury, infectious or inflammatory respiratory disease, and airway collapse. Results Dogs ranged in age from 0.5 to 16 years (median, 7.9 years) and had a median body weight of 11.4 kg (range, 2.0‐42.7 kg). Eosinophilic lung disease was documented in 13 of 104 dogs (Group 1) and airway neutrophilia associated with infectious or inflammatory disease was found in 59 of 104 dogs (Group 2). Lymphocytosis alone in BAL fluid was described in 32 dogs (Group 3). Duration of cough did not differ among groups, but airway collapse was significantly more common in dogs with solitary lymphocytosis than in those with other types of inflammation. Conclusions and Clinical Importance Lymphocytosis in BAL fluid is common in dogs and, in many cases, likely represents a common response to airway injury, independent of the type or duration of insult. It is unknown whether airway collapse leads to lymphocytosis or if the inflammatory process causes airway collapse.https://doi.org/10.1111/jvim.15489bronchitisbronchomalaciaeosinophilic lung diseaseinfection |
| spellingShingle | Lynelle R. Johnson William Vernau Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006‐2016) Journal of Veterinary Internal Medicine bronchitis bronchomalacia eosinophilic lung disease infection |
| title | Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006‐2016) |
| title_full | Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006‐2016) |
| title_fullStr | Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006‐2016) |
| title_full_unstemmed | Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006‐2016) |
| title_short | Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006‐2016) |
| title_sort | bronchoalveolar lavage fluid lymphocytosis in 104 dogs 2006 2016 |
| topic | bronchitis bronchomalacia eosinophilic lung disease infection |
| url | https://doi.org/10.1111/jvim.15489 |
| work_keys_str_mv | AT lynellerjohnson bronchoalveolarlavagefluidlymphocytosisin104dogs20062016 AT williamvernau bronchoalveolarlavagefluidlymphocytosisin104dogs20062016 |