Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury.
The extent of pulmonary inflammation during lung injury ultimately determines patient outcome. Pulmonary inflammation is initiated by the migration of neutrophils into the alveolar space. Recent work has demonstrated that the guidance protein semaphorin 7A (SEMA7A) influences the migration of neutro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4720127?pdf=render |
| _version_ | 1818316370951012352 |
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| author | Judith Marlene Roth David Köhler Mariella Schneider Tiago Folgosa Granja Peter Rosenberger |
| author_facet | Judith Marlene Roth David Köhler Mariella Schneider Tiago Folgosa Granja Peter Rosenberger |
| author_sort | Judith Marlene Roth |
| collection | DOAJ |
| description | The extent of pulmonary inflammation during lung injury ultimately determines patient outcome. Pulmonary inflammation is initiated by the migration of neutrophils into the alveolar space. Recent work has demonstrated that the guidance protein semaphorin 7A (SEMA7A) influences the migration of neutrophils into hypoxic tissue sites, yet, its role during lung injury is not well understood. Here, we report that the expression of SEMA7A is induced in vitro through pro-inflammatory cytokines. SEMA7A itself induces the production of pro-inflammatory cytokines in endothelial and epithelial cells, enhancing pulmonary inflammation. The induction of SEMA7A facilitates the transendothelial migration of neutrophils. In vivo, animals with deletion of SEMA7A expression showed reduced signs of pulmonary inflammatory changes following lipopolysaccharide challenge. We define here the role of SEMA7A in the development of lung injury and identify a potential pathway to interfere with these detrimental changes. Future anti-inflammatory strategies for the treatment of lung injury might be based on this finding. |
| first_indexed | 2024-12-13T09:20:22Z |
| format | Article |
| id | doaj.art-db9a2db4ce3b4fe89bafa3d37317cdc2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T09:20:22Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-db9a2db4ce3b4fe89bafa3d37317cdc22022-12-21T23:52:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014693010.1371/journal.pone.0146930Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury.Judith Marlene RothDavid KöhlerMariella SchneiderTiago Folgosa GranjaPeter RosenbergerThe extent of pulmonary inflammation during lung injury ultimately determines patient outcome. Pulmonary inflammation is initiated by the migration of neutrophils into the alveolar space. Recent work has demonstrated that the guidance protein semaphorin 7A (SEMA7A) influences the migration of neutrophils into hypoxic tissue sites, yet, its role during lung injury is not well understood. Here, we report that the expression of SEMA7A is induced in vitro through pro-inflammatory cytokines. SEMA7A itself induces the production of pro-inflammatory cytokines in endothelial and epithelial cells, enhancing pulmonary inflammation. The induction of SEMA7A facilitates the transendothelial migration of neutrophils. In vivo, animals with deletion of SEMA7A expression showed reduced signs of pulmonary inflammatory changes following lipopolysaccharide challenge. We define here the role of SEMA7A in the development of lung injury and identify a potential pathway to interfere with these detrimental changes. Future anti-inflammatory strategies for the treatment of lung injury might be based on this finding.http://europepmc.org/articles/PMC4720127?pdf=render |
| spellingShingle | Judith Marlene Roth David Köhler Mariella Schneider Tiago Folgosa Granja Peter Rosenberger Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. PLoS ONE |
| title | Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. |
| title_full | Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. |
| title_fullStr | Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. |
| title_full_unstemmed | Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. |
| title_short | Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury. |
| title_sort | semaphorin 7a aggravates pulmonary inflammation during lung injury |
| url | http://europepmc.org/articles/PMC4720127?pdf=render |
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