Application of conductive hydrogels in cardiac tissue engineering
The fatality rate of myocardial infarction ranks first in cardiovascular disease, which is myocardial necrosis caused by persistent ischemia and hypoxia caused by coronary artery occlusion. Myocardial infarction leads to the irreversible loss of a large number of cardiomyocytes. Exogenous cardiomyo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Innovation Publishing House Pte. Ltd.
2023-04-01
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| Series: | STEMedicine |
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| Online Access: | http://stemedicine.org/index.php/stem/article/view/169 |
| _version_ | 1797853017847889920 |
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| author | Xiaoyi Ren Ziyun Jiang Mingliang Tang |
| author_facet | Xiaoyi Ren Ziyun Jiang Mingliang Tang |
| author_sort | Xiaoyi Ren |
| collection | DOAJ |
| description |
The fatality rate of myocardial infarction ranks first in cardiovascular disease, which is myocardial necrosis caused by persistent ischemia and hypoxia caused by coronary artery occlusion. Myocardial infarction leads to the irreversible loss of a large number of cardiomyocytes. Exogenous cardiomyocyte supplement is an ideal method for the treatment of myocardial infarction. However, myocardial infarction leads to the loss of electrical conductivity of myocardial tissue at the infarcted site, and it is difficult for exogenous cardiomyocytes to integrate effectively. So, it is necessary to reshape the microenvironment of the infarcted site and restore its electrical conductivity. The construction of heart tissue engineering combined with biomaterials, cells and bioactive molecules is a hot topic in recent years. Conductive hydrogels, as an ideal scaffold material can promote the maturation of cardiomyocytes in vitro, give effective mechanical support to the infarcted site, improve the electrical conductivity of infarcted tissue, help exogenous cardiomyocytes integrate in vivo and restore heart function gradually. In this paper, we review the natural substrate materials used to make conductive hydrogels, the emerging trend of conductive materials and the applications of conductive hydrogels in heart tissue engineering.
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| first_indexed | 2024-04-09T19:43:48Z |
| format | Article |
| id | doaj.art-db9bc534aa084720ac43a66ba047a033 |
| institution | Directory Open Access Journal |
| issn | 2705-1188 |
| language | English |
| last_indexed | 2024-04-09T19:43:48Z |
| publishDate | 2023-04-01 |
| publisher | Innovation Publishing House Pte. Ltd. |
| record_format | Article |
| series | STEMedicine |
| spelling | doaj.art-db9bc534aa084720ac43a66ba047a0332023-04-03T23:08:53ZengInnovation Publishing House Pte. Ltd.STEMedicine2705-11882023-04-014210.37175/stemedicine.v4i2.169Application of conductive hydrogels in cardiac tissue engineeringXiaoyi Ren0Ziyun Jiang1Mingliang Tang2Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, 215000, ChinaInstitute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, 215000, ChinaInstitute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, 215000, China; and Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China The fatality rate of myocardial infarction ranks first in cardiovascular disease, which is myocardial necrosis caused by persistent ischemia and hypoxia caused by coronary artery occlusion. Myocardial infarction leads to the irreversible loss of a large number of cardiomyocytes. Exogenous cardiomyocyte supplement is an ideal method for the treatment of myocardial infarction. However, myocardial infarction leads to the loss of electrical conductivity of myocardial tissue at the infarcted site, and it is difficult for exogenous cardiomyocytes to integrate effectively. So, it is necessary to reshape the microenvironment of the infarcted site and restore its electrical conductivity. The construction of heart tissue engineering combined with biomaterials, cells and bioactive molecules is a hot topic in recent years. Conductive hydrogels, as an ideal scaffold material can promote the maturation of cardiomyocytes in vitro, give effective mechanical support to the infarcted site, improve the electrical conductivity of infarcted tissue, help exogenous cardiomyocytes integrate in vivo and restore heart function gradually. In this paper, we review the natural substrate materials used to make conductive hydrogels, the emerging trend of conductive materials and the applications of conductive hydrogels in heart tissue engineering. http://stemedicine.org/index.php/stem/article/view/169myocardial infarctionheart tissue engineeringconductive hydrogels |
| spellingShingle | Xiaoyi Ren Ziyun Jiang Mingliang Tang Application of conductive hydrogels in cardiac tissue engineering STEMedicine myocardial infarction heart tissue engineering conductive hydrogels |
| title | Application of conductive hydrogels in cardiac tissue engineering |
| title_full | Application of conductive hydrogels in cardiac tissue engineering |
| title_fullStr | Application of conductive hydrogels in cardiac tissue engineering |
| title_full_unstemmed | Application of conductive hydrogels in cardiac tissue engineering |
| title_short | Application of conductive hydrogels in cardiac tissue engineering |
| title_sort | application of conductive hydrogels in cardiac tissue engineering |
| topic | myocardial infarction heart tissue engineering conductive hydrogels |
| url | http://stemedicine.org/index.php/stem/article/view/169 |
| work_keys_str_mv | AT xiaoyiren applicationofconductivehydrogelsincardiactissueengineering AT ziyunjiang applicationofconductivehydrogelsincardiactissueengineering AT mingliangtang applicationofconductivehydrogelsincardiactissueengineering |