Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico
Background Cervical cancer (CC) is the fourth most common malignancy of the female genital tract. Human Papillomavirus (HPV) is the main cause of precancerous lesions and CC cases worldwide Objective We assessed the prevalence and distribution of HPV types and their association with precancerous les...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748221103331 |
| _version_ | 1811255569029267456 |
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| author | Luz del Carmen Alarcón-Romero PhD Jorge Organista-Nava PhD Yazmín Gómez-Gómez PhD Julio Ortiz-Ortiz PhD Daniel Hernández-Sotelo PhD Oscar del Moral-Hernández PhD Miguel Angel Mendoza-Catalán PhD Ramón Antaño-Arias PhD Marco Antonio Leyva-Vázquez PhD Natividad Sales-Linares BSc Verónica Antonio-Véjar PhD Berenice Illades-Aguiar PhD |
| author_facet | Luz del Carmen Alarcón-Romero PhD Jorge Organista-Nava PhD Yazmín Gómez-Gómez PhD Julio Ortiz-Ortiz PhD Daniel Hernández-Sotelo PhD Oscar del Moral-Hernández PhD Miguel Angel Mendoza-Catalán PhD Ramón Antaño-Arias PhD Marco Antonio Leyva-Vázquez PhD Natividad Sales-Linares BSc Verónica Antonio-Véjar PhD Berenice Illades-Aguiar PhD |
| author_sort | Luz del Carmen Alarcón-Romero PhD |
| collection | DOAJ |
| description | Background Cervical cancer (CC) is the fourth most common malignancy of the female genital tract. Human Papillomavirus (HPV) is the main cause of precancerous lesions and CC cases worldwide Objective We assessed the prevalence and distribution of HPV types and their association with precancerous lesions and CC. Methods HPV genotypes were detected by 3 methods depending on the year of in which the sample was analyzed: MY09/11 RFLPs (1997 to 2010), GP5+/6+ primer systems (2005 to 2010) and INNO-LiPA HPV Genotyping Extra (2010 to 2019) in cervical samples (No-IL: 4445; LSIL: 2464; HSILs: 151 and CC: 253) from women from southern Mexico. Results The overall HPV prevalence was 54.17%, and hpv-16 was the most common genotype. In single infection, the high-risk HPV genotypes (group 1) were associated with squamous intraepitelial lesions (LSIL: HPV–39 (OR = 10.58, 95% CI 4.09–27.36, P < .001); HSIL: HPV-31 (OR = 14.76, 95% CI 6.56–33.20, P < .001); and CC: HPV-16 (OR = 25.01, 95% CI 18.83–33.21, P < .001). In multiple infections, the HPV genotypes (HPV-16 and HPV-18) were also associated with a high risk of lesions [LSIL: HPV-18 (OR = 3.45; 95% CI 1.36–8.91; P = .009); HSIL: HPV-18 (OR = 5.12; 95% CI 1.21–21.68; P = .026); and CC: HPV-16 (OR = 3.03; 95% CI 1.72–5.32; P < .001)] compared to single infection. In the analysis adjusted for age, giving birth, and cigarette smoking, a significant increase in the risk of LSIL, HSIL, and CC was maintained. Conclusions This study provides current data on the prevalence and distribution of HPV genotypes in women from southern Mexico, which could serve as a valuable reference to guide nationwide CC screening programs and provide scientific evidence that could be useful for vaccine development efforts. Likewise, it was identified that infection with carcinogenic HPV genotypes is an independent risk factor for LSIL, HSIL, and CC. |
| first_indexed | 2024-04-12T17:25:49Z |
| format | Article |
| id | doaj.art-db9c71a90c5440878fe780c485630b64 |
| institution | Directory Open Access Journal |
| issn | 1073-2748 |
| language | English |
| last_indexed | 2024-04-12T17:25:49Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-db9c71a90c5440878fe780c485630b642022-12-22T03:23:18ZengSAGE PublishingCancer Control1073-27482022-05-012910.1177/10732748221103331Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern MexicoLuz del Carmen Alarcón-Romero PhDJorge Organista-Nava PhDYazmín Gómez-Gómez PhDJulio Ortiz-Ortiz PhDDaniel Hernández-Sotelo PhDOscar del Moral-Hernández PhDMiguel Angel Mendoza-Catalán PhDRamón Antaño-Arias PhDMarco Antonio Leyva-Vázquez PhDNatividad Sales-Linares BScVerónica Antonio-Véjar PhDBerenice Illades-Aguiar PhDBackground Cervical cancer (CC) is the fourth most common malignancy of the female genital tract. Human Papillomavirus (HPV) is the main cause of precancerous lesions and CC cases worldwide Objective We assessed the prevalence and distribution of HPV types and their association with precancerous lesions and CC. Methods HPV genotypes were detected by 3 methods depending on the year of in which the sample was analyzed: MY09/11 RFLPs (1997 to 2010), GP5+/6+ primer systems (2005 to 2010) and INNO-LiPA HPV Genotyping Extra (2010 to 2019) in cervical samples (No-IL: 4445; LSIL: 2464; HSILs: 151 and CC: 253) from women from southern Mexico. Results The overall HPV prevalence was 54.17%, and hpv-16 was the most common genotype. In single infection, the high-risk HPV genotypes (group 1) were associated with squamous intraepitelial lesions (LSIL: HPV–39 (OR = 10.58, 95% CI 4.09–27.36, P < .001); HSIL: HPV-31 (OR = 14.76, 95% CI 6.56–33.20, P < .001); and CC: HPV-16 (OR = 25.01, 95% CI 18.83–33.21, P < .001). In multiple infections, the HPV genotypes (HPV-16 and HPV-18) were also associated with a high risk of lesions [LSIL: HPV-18 (OR = 3.45; 95% CI 1.36–8.91; P = .009); HSIL: HPV-18 (OR = 5.12; 95% CI 1.21–21.68; P = .026); and CC: HPV-16 (OR = 3.03; 95% CI 1.72–5.32; P < .001)] compared to single infection. In the analysis adjusted for age, giving birth, and cigarette smoking, a significant increase in the risk of LSIL, HSIL, and CC was maintained. Conclusions This study provides current data on the prevalence and distribution of HPV genotypes in women from southern Mexico, which could serve as a valuable reference to guide nationwide CC screening programs and provide scientific evidence that could be useful for vaccine development efforts. Likewise, it was identified that infection with carcinogenic HPV genotypes is an independent risk factor for LSIL, HSIL, and CC.https://doi.org/10.1177/10732748221103331 |
| spellingShingle | Luz del Carmen Alarcón-Romero PhD Jorge Organista-Nava PhD Yazmín Gómez-Gómez PhD Julio Ortiz-Ortiz PhD Daniel Hernández-Sotelo PhD Oscar del Moral-Hernández PhD Miguel Angel Mendoza-Catalán PhD Ramón Antaño-Arias PhD Marco Antonio Leyva-Vázquez PhD Natividad Sales-Linares BSc Verónica Antonio-Véjar PhD Berenice Illades-Aguiar PhD Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico Cancer Control |
| title | Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico |
| title_full | Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico |
| title_fullStr | Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico |
| title_full_unstemmed | Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico |
| title_short | Prevalence and Distribution of Human Papillomavirus Genotypes (1997–2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico |
| title_sort | prevalence and distribution of human papillomavirus genotypes 1997 2019 and their association with cervical cancer and precursor lesions in women from southern mexico |
| url | https://doi.org/10.1177/10732748221103331 |
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