Analysis of mutant allele fractions in driver genes in colorectal cancer – biological and clinical insights

Analysis of mutant allele fractions in driver genes in colorectal cancer – biological and clinical insights

Sequencing of tumors is now routine and guides personalized cancer therapy. Mutant allele fractions (MAFs, or the ‘mutation dose’) of a driver gene may reveal the genomic structure of tumors and influence response to targeted therapies. We performed a comprehensive analysis of MAFs of driver alterat...

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Bibliographic Details
Main Authors: Rodrigo Dienstmann, Elena Elez, Guillem Argiles, Ignacio Matos, Enrique Sanz‐Garcia, Carolina Ortiz, Teresa Macarulla, Jaume Capdevila, Maria Alsina, Tamara Sauri, Helena Verdaguer, Marta Vilaro, Fiorella Ruiz‐Pace, Cristina Viaplana, Ariadna Garcia, Stefania Landolfi, Hector G. Palmer, Paolo Nuciforo, Jordi Rodon, Ana Vivancos, Josep Tabernero
Format: Article
Language:English
Published: Wiley 2017-09-01
Series:Molecular Oncology
Subjects:
clonality
colorectal cancer
driver gene
mutant allele fraction
Online Access:https://doi.org/10.1002/1878-0261.12099

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