Investigating the Role of the N-Terminal Loop of PD-1 in Binding Process Between PD-1 and Nivolumab via Molecular Dynamics Simulation

Investigating the Role of the N-Terminal Loop of PD-1 in Binding Process Between PD-1 and Nivolumab via Molecular Dynamics Simulation

The blockade of immune checkpoints, such as programmed death receptor 1 (PD-1) and programmed death ligand 1 protein (PD-L1), is a promising therapeutic approach in cancer immunotherapy. Nivolumab, a humanized IgG4 antibody targeting PD-1, was approved by the US Food and Drug Administration for seve...

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Bibliographic Details
Main Authors: Wenping Liu, Haoyu Jin, Ting Chen, Gangping Zhang, Shengsheng Lai, Guangjian Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
PD-1
nivolumab
N-terminal loop
molecular dynamics simulation
two-step model
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.574759/full

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