Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor setting
Food-borne botulism is a rare, acute and potentially fatal neurologic disorder that results from ingestion of food contaminated by botulinum toxin released from the anaerobic, spore-forming, gram-positive bacterium Clostridium botulinum. We reported an unusual cluster of botulism outbreak with high...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2020-08-01
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| Series: | The Pan African Medical Journal |
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| Online Access: |
https://www.panafrican-med-journal.com/content/article/36/287/pdf/287.pdf
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| _version_ | 1819121779484917760 |
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| author | Oyeladun Okunromade Mahmood Muazu Dalhat Aminatu Makarfi Umar Augustine Olajide Dada Jamilu Nikau Lamin Maneh Okokon Ita Ita Muhammad Shakir Balogun Patrick Nguku Olubunmi Ojo Chikwe Ihekweazu |
| author_facet | Oyeladun Okunromade Mahmood Muazu Dalhat Aminatu Makarfi Umar Augustine Olajide Dada Jamilu Nikau Lamin Maneh Okokon Ita Ita Muhammad Shakir Balogun Patrick Nguku Olubunmi Ojo Chikwe Ihekweazu |
| author_sort | Oyeladun Okunromade |
| collection | DOAJ |
| description | Food-borne botulism is a rare, acute and potentially fatal neurologic disorder that results from ingestion of food contaminated by botulinum toxin released from the anaerobic, spore-forming, gram-positive bacterium Clostridium botulinum. We reported an unusual cluster of botulism outbreak with high case fatality affecting a family following ingestion of home-made fish. A suspected outbreak of botulism affecting three patients in a family of six was reported to the Nigeria Centre for Disease Control. A rapid response team investigated by line-listing all the family members, interviewed extended family members, caregivers, clinicians, and nurses to collect socio-demographic and clinicoepidemiological information using a semi-structured questionnaires. We collected blood from patients and food samples and locally made drink from the family home for laboratory testing. All family members ingested the same home-made food within the 48hrs before onset of symptoms in the index case. The clinical presentation of the three affected cases (AR=50.0%) was consistent with botulinum poisoning. Two of the affected cases died (CFR=66.7%) within 48hrs of admission before antitoxin was made available. The third case had a milder presentation and survived, after administration of appropriate antitoxin. The remaining three children developed no symptoms. None of the samples cultured clostridium botulinum. The blood samples were negative for mouse lethality test. Our report describes the challenges of diagnosis and management of rare emerging infectious disease outbreaks in resource-constrained settings. |
| first_indexed | 2024-12-22T06:41:59Z |
| format | Article |
| id | doaj.art-db9df8d8449c47f8ab760fc668942c9b |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-22T06:41:59Z |
| publishDate | 2020-08-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-db9df8d8449c47f8ab760fc668942c9b2022-12-21T18:35:24ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882020-08-013628710.11604/pamj.2020.36.287.2087220872Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor settingOyeladun Okunromade0Mahmood Muazu Dalhat1Aminatu Makarfi Umar2Augustine Olajide Dada3Jamilu Nikau4Lamin Maneh5Okokon Ita Ita6Muhammad Shakir Balogun7Patrick Nguku8Olubunmi Ojo9Chikwe Ihekweazu10 Nigeria Centre for Disease Control, Abuja, Nigeria Nigeria Field Epidemiology and Laboratory Training Programme,Abuja, Nigeria Nigeria Field Epidemiology and Laboratory Training Programme,Abuja, Nigeria Nigeria Field Epidemiology and Laboratory Training Programme,Abuja, Nigeria Nigeria Field Epidemiology and Laboratory Training Programme,Abuja, Nigeria Nigeria Field Epidemiology and Laboratory Training Programme,Abuja, Nigeria Nigeria Field Epidemiology and Laboratory Training Programme,Abuja, Nigeria Nigeria Field Epidemiology and Laboratory Training Programme,Abuja, Nigeria Nigeria Field Epidemiology and Laboratory Training Programme,Abuja, Nigeria Nigeria Centre for Disease Control, Abuja, Nigeria Nigeria Centre for Disease Control, Abuja, Nigeria Food-borne botulism is a rare, acute and potentially fatal neurologic disorder that results from ingestion of food contaminated by botulinum toxin released from the anaerobic, spore-forming, gram-positive bacterium Clostridium botulinum. We reported an unusual cluster of botulism outbreak with high case fatality affecting a family following ingestion of home-made fish. A suspected outbreak of botulism affecting three patients in a family of six was reported to the Nigeria Centre for Disease Control. A rapid response team investigated by line-listing all the family members, interviewed extended family members, caregivers, clinicians, and nurses to collect socio-demographic and clinicoepidemiological information using a semi-structured questionnaires. We collected blood from patients and food samples and locally made drink from the family home for laboratory testing. All family members ingested the same home-made food within the 48hrs before onset of symptoms in the index case. The clinical presentation of the three affected cases (AR=50.0%) was consistent with botulinum poisoning. Two of the affected cases died (CFR=66.7%) within 48hrs of admission before antitoxin was made available. The third case had a milder presentation and survived, after administration of appropriate antitoxin. The remaining three children developed no symptoms. None of the samples cultured clostridium botulinum. The blood samples were negative for mouse lethality test. Our report describes the challenges of diagnosis and management of rare emerging infectious disease outbreaks in resource-constrained settings. https://www.panafrican-med-journal.com/content/article/36/287/pdf/287.pdf : case reportbotulismanti-toxinbotulinummouse assay |
| spellingShingle | Oyeladun Okunromade Mahmood Muazu Dalhat Aminatu Makarfi Umar Augustine Olajide Dada Jamilu Nikau Lamin Maneh Okokon Ita Ita Muhammad Shakir Balogun Patrick Nguku Olubunmi Ojo Chikwe Ihekweazu Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor setting The Pan African Medical Journal : case report botulism anti-toxin botulinum mouse assay |
| title | Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor setting |
| title_full | Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor setting |
| title_fullStr | Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor setting |
| title_full_unstemmed | Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor setting |
| title_short | Emergency response to a cluster of suspected food-borne botulism in Abuja, Nigeria: challenges with diagnosis and treatment in a resource-poor setting |
| title_sort | emergency response to a cluster of suspected food borne botulism in abuja nigeria challenges with diagnosis and treatment in a resource poor setting |
| topic | : case report botulism anti-toxin botulinum mouse assay |
| url |
https://www.panafrican-med-journal.com/content/article/36/287/pdf/287.pdf
|
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