THE THERAPEUTIC CHALLENGES OF A „LARGE IMITATOR“ – THE GENERALIZED RING GRANULOMA
Granuloma annulare (GA) is a benign skin condition of unknown etiology. It can manifest itself in several clinical forms: localized, generalized, subcutaneous or perforating. The association between GI and diabetes, dyslipidemia or neoplasms is not yet elucidated. Although the diagnosis is clinica...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2019-12-01
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| Series: | Romanian Medical Journal |
| Subjects: | |
| Online Access: | https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.4/RMJ_2019_4_Art-20.pdf |
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| author | Florica Șandru Adelina Popa Mihai Cristian Dumitrașcu Carmen Cristina Drăghici Ana Maria Alexandra Stănescu Raluca-Gabriela Miulescu |
| author_facet | Florica Șandru Adelina Popa Mihai Cristian Dumitrașcu Carmen Cristina Drăghici Ana Maria Alexandra Stănescu Raluca-Gabriela Miulescu |
| author_sort | Florica Șandru |
| collection | DOAJ |
| description | Granuloma annulare (GA) is a benign skin condition of unknown etiology. It can manifest itself in several
clinical forms: localized, generalized, subcutaneous or perforating. The association between GI and diabetes,
dyslipidemia or neoplasms is not yet elucidated. Although the diagnosis is clinical in most cases, a histopathological examination may be necessary.
We presented the case of a 52 years old patient, diabetic, hypertensive, who reffered to our clinic, with a rash
or macular-papular, pruritic, eruption, localization on the lower limbs and abdomen, in the evolution of 6
months. We performed skin biopsy with histopathological examination, which revealed: dermal nodular infiltrates consisting of palisadiate histiocytes, in several mucin collections and signified by lymphocytes with
perivascular arrangement, typical modifications for an annular granuloma lesion. We have initiated systemic
treatment with isotretinoin, associated with dermatocorticoids, with favorable evolution.
Diagnosis, aș well aș the management of a patient with generalized GI, can sometimes be difficult. The histopathological examination, in combination with a suggestive clinical picture, makes the diagnosis. Treatment is indicated in severe cases, with multiple, symptomatic, persistent lesions. |
| first_indexed | 2024-03-08T07:52:16Z |
| format | Article |
| id | doaj.art-db9efe9856b04649b4ca0f4f90948b2a |
| institution | Directory Open Access Journal |
| issn | 1220-5478 2069-606X |
| language | English |
| last_indexed | 2024-03-08T07:52:16Z |
| publishDate | 2019-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj.art-db9efe9856b04649b4ca0f4f90948b2a2024-02-02T14:38:28ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2019-12-0166440941110.37897/RMJ.2019.4.20THE THERAPEUTIC CHALLENGES OF A „LARGE IMITATOR“ – THE GENERALIZED RING GRANULOMAFlorica Șandru0Adelina Popa1Mihai Cristian Dumitrașcu2Carmen Cristina Drăghici3Ana Maria Alexandra Stănescu4Raluca-Gabriela Miulescu5Departamentul de Dermatologie, Spitalul Universitar de Urgență Elias, București, România; Universitatea de Medicină și Farmacie „Carol Davila“, București, RomâniaDepartamentul de Dermatologie, Spitalul Universitar de Urgență Elias, București, RomâniaUniversitatea de Medicină și Farmacie „Carol Davila“, București, România; Departamentul de Obstetrică-Ginecologie, Spitalul Universitar de Urgență, București, RomâniaDepartamentul de Dermatologie, Spitalul Universitar de Urgență Elias, București, România Universitatea de Medicină și Farmacie „Carol Davila“, București, RomâniaDepartamentul de Dermatologie, Spitalul Universitar de Urgență Elias, București, RomâniaGranuloma annulare (GA) is a benign skin condition of unknown etiology. It can manifest itself in several clinical forms: localized, generalized, subcutaneous or perforating. The association between GI and diabetes, dyslipidemia or neoplasms is not yet elucidated. Although the diagnosis is clinical in most cases, a histopathological examination may be necessary. We presented the case of a 52 years old patient, diabetic, hypertensive, who reffered to our clinic, with a rash or macular-papular, pruritic, eruption, localization on the lower limbs and abdomen, in the evolution of 6 months. We performed skin biopsy with histopathological examination, which revealed: dermal nodular infiltrates consisting of palisadiate histiocytes, in several mucin collections and signified by lymphocytes with perivascular arrangement, typical modifications for an annular granuloma lesion. We have initiated systemic treatment with isotretinoin, associated with dermatocorticoids, with favorable evolution. Diagnosis, aș well aș the management of a patient with generalized GI, can sometimes be difficult. The histopathological examination, in combination with a suggestive clinical picture, makes the diagnosis. Treatment is indicated in severe cases, with multiple, symptomatic, persistent lesions.https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.4/RMJ_2019_4_Art-20.pdfgranuloma annulareisotretinoindermatocorticoidsdapsone |
| spellingShingle | Florica Șandru Adelina Popa Mihai Cristian Dumitrașcu Carmen Cristina Drăghici Ana Maria Alexandra Stănescu Raluca-Gabriela Miulescu THE THERAPEUTIC CHALLENGES OF A „LARGE IMITATOR“ – THE GENERALIZED RING GRANULOMA Romanian Medical Journal granuloma annulare isotretinoin dermatocorticoids dapsone |
| title | THE THERAPEUTIC CHALLENGES OF A „LARGE IMITATOR“ – THE GENERALIZED RING GRANULOMA |
| title_full | THE THERAPEUTIC CHALLENGES OF A „LARGE IMITATOR“ – THE GENERALIZED RING GRANULOMA |
| title_fullStr | THE THERAPEUTIC CHALLENGES OF A „LARGE IMITATOR“ – THE GENERALIZED RING GRANULOMA |
| title_full_unstemmed | THE THERAPEUTIC CHALLENGES OF A „LARGE IMITATOR“ – THE GENERALIZED RING GRANULOMA |
| title_short | THE THERAPEUTIC CHALLENGES OF A „LARGE IMITATOR“ – THE GENERALIZED RING GRANULOMA |
| title_sort | therapeutic challenges of a large imitator the generalized ring granuloma |
| topic | granuloma annulare isotretinoin dermatocorticoids dapsone |
| url | https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.4/RMJ_2019_4_Art-20.pdf |
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