Resveratrol protects mitochondrial quantity by activating SIRT1/PGC‐1α expression during ovarian hypoxia

Resveratrol protects mitochondrial quantity by activating SIRT1/PGC‐1α expression during ovarian hypoxia

Abstract Purpose Resveratrol is a well‐known potent activator of sirtuin‐1 (SIRT1). We investigated the direct effects of hypoxia and resveratrol on SIRT1/ peroxisome proliferator‐activated receptor‐gamma coactivator 1α (PGC‐1α) pathways, vascular endothelial growth factor (VEGF), hypoxia‐inducible...

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Bibliographic Details
Main Authors:	Akemi Nishigaki, Takeharu Kido, Naoko Kida, Maiko Kakita‐Kobayashi, Hiroaki Tsubokura, Yoji Hisamatsu, Hidetaka Okada
Format:	Article
Language:	English
Published:	Wiley 2020-04-01
Series:	Reproductive Medicine and Biology
Subjects:	hypoxia‐inducible factor‐1α mitochondrial DNA copy number PGC‐1α resveratrol sirtuin‐1
Online Access:	https://doi.org/10.1002/rmb2.12323

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