Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis.

Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis.

Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second stage HAT, where parasites have invaded the central nervous system (CNS). The...

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Bibliographic Details
Main Authors: John K Thuita, Michael Z Wang, John M Kagira, Cathrine L Denton, Mary F Paine, Raymond E Mdachi, Grace A Murilla, Shelley Ching, David W Boykin, Richard R Tidwell, James E Hall, Reto Brun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3404106?pdf=render

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