The Pathophysiology of H<sub>2</sub>S in Renal Glomerular Diseases
Renal glomerular diseases such as glomerulosclerosis and diabetic nephropathy often result in the loss of glomerular function and consequently end-stage renal disease. The glomerulus consists of endothelial cells, mesangial cells and glomerular epithelial cells also referred to as podocytes. A fine-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/2/207 |
| _version_ | 1827656578354905088 |
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| author | Karl-Friedrich Beck Josef Pfeilschifter |
| author_facet | Karl-Friedrich Beck Josef Pfeilschifter |
| author_sort | Karl-Friedrich Beck |
| collection | DOAJ |
| description | Renal glomerular diseases such as glomerulosclerosis and diabetic nephropathy often result in the loss of glomerular function and consequently end-stage renal disease. The glomerulus consists of endothelial cells, mesangial cells and glomerular epithelial cells also referred to as podocytes. A fine-tuned crosstalk between glomerular cells warrants control of growth factor synthesis and of matrix production and degradation, preserving glomerular structure and function. Hydrogen sulfide (H<sub>2</sub>S) belongs together with nitric oxide (NO) and carbon monoxide (CO) to the group of gasotransmitters. During the last three decades, these higher concentration toxic gases have been found to be produced in mammalian cells in a well-coordinated manner. Recently, it became evident that H<sub>2</sub>S and the other gasotransmitters share common targets as signalling devices that trigger mainly protective pathways. In several animal models, H<sub>2</sub>S has been demonstrated as a protective factor in the context of kidney disorders, in particular of diabetic nephropathy. Here, we focus on the synthesis and action of H<sub>2</sub>S in glomerular cells, its beneficial effects in the glomerulus and its action in the context of the other gaseous signalling molecules NO and CO. |
| first_indexed | 2024-03-09T22:30:19Z |
| format | Article |
| id | doaj.art-dba0d500c7e1472fb8f41ad7db1d134b |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T22:30:19Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-dba0d500c7e1472fb8f41ad7db1d134b2023-11-23T18:58:12ZengMDPI AGBiomolecules2218-273X2022-01-0112220710.3390/biom12020207The Pathophysiology of H<sub>2</sub>S in Renal Glomerular DiseasesKarl-Friedrich Beck0Josef Pfeilschifter1Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Goethe-Universität, 60590 Frankfurt am Main, GermanyPharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Goethe-Universität, 60590 Frankfurt am Main, GermanyRenal glomerular diseases such as glomerulosclerosis and diabetic nephropathy often result in the loss of glomerular function and consequently end-stage renal disease. The glomerulus consists of endothelial cells, mesangial cells and glomerular epithelial cells also referred to as podocytes. A fine-tuned crosstalk between glomerular cells warrants control of growth factor synthesis and of matrix production and degradation, preserving glomerular structure and function. Hydrogen sulfide (H<sub>2</sub>S) belongs together with nitric oxide (NO) and carbon monoxide (CO) to the group of gasotransmitters. During the last three decades, these higher concentration toxic gases have been found to be produced in mammalian cells in a well-coordinated manner. Recently, it became evident that H<sub>2</sub>S and the other gasotransmitters share common targets as signalling devices that trigger mainly protective pathways. In several animal models, H<sub>2</sub>S has been demonstrated as a protective factor in the context of kidney disorders, in particular of diabetic nephropathy. Here, we focus on the synthesis and action of H<sub>2</sub>S in glomerular cells, its beneficial effects in the glomerulus and its action in the context of the other gaseous signalling molecules NO and CO.https://www.mdpi.com/2218-273X/12/2/207hydrogen sulfide (H<sub>2</sub>S)gasotransmittersglomerulusmesangial cells |
| spellingShingle | Karl-Friedrich Beck Josef Pfeilschifter The Pathophysiology of H<sub>2</sub>S in Renal Glomerular Diseases Biomolecules hydrogen sulfide (H<sub>2</sub>S) gasotransmitters glomerulus mesangial cells |
| title | The Pathophysiology of H<sub>2</sub>S in Renal Glomerular Diseases |
| title_full | The Pathophysiology of H<sub>2</sub>S in Renal Glomerular Diseases |
| title_fullStr | The Pathophysiology of H<sub>2</sub>S in Renal Glomerular Diseases |
| title_full_unstemmed | The Pathophysiology of H<sub>2</sub>S in Renal Glomerular Diseases |
| title_short | The Pathophysiology of H<sub>2</sub>S in Renal Glomerular Diseases |
| title_sort | pathophysiology of h sub 2 sub s in renal glomerular diseases |
| topic | hydrogen sulfide (H<sub>2</sub>S) gasotransmitters glomerulus mesangial cells |
| url | https://www.mdpi.com/2218-273X/12/2/207 |
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