Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping
Abstract Background Despite existing extensive literature, a comprehensive and clinically relevant classification system for osteoarthritis (OA) has yet to be established. In this study, we aimed to further characterize four knee OA (KOA) inflammatory phenotypes (KOIP) recently proposed by our group...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13075-023-03244-y |
| _version_ | 1797355609575653376 |
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| author | Joan Calvet Antoni Berenguer-Llergo Cristóbal Orellana María García-Manrique Menna Rusiñol Silvia Garcia-Cirera Maria Llop Marta Arévalo Alba Garcia-Pinilla Carlos Galisteo Cristina Aymerich Rafael Gómez Alejandra Serrano Anna Carreras Jordi Gratacós |
| author_facet | Joan Calvet Antoni Berenguer-Llergo Cristóbal Orellana María García-Manrique Menna Rusiñol Silvia Garcia-Cirera Maria Llop Marta Arévalo Alba Garcia-Pinilla Carlos Galisteo Cristina Aymerich Rafael Gómez Alejandra Serrano Anna Carreras Jordi Gratacós |
| author_sort | Joan Calvet |
| collection | DOAJ |
| description | Abstract Background Despite existing extensive literature, a comprehensive and clinically relevant classification system for osteoarthritis (OA) has yet to be established. In this study, we aimed to further characterize four knee OA (KOA) inflammatory phenotypes (KOIP) recently proposed by our group, by identifying the inflammatory factors associated with KOA severity and progression in a phenotype-specific manner. Methods We performed an analysis within each of the previously defined four KOIP groups, to assess the association between KOA severity and progression and a panel of 13 cytokines evaluated in the plasma and synovial fluid of our cohort’s patients. The cohort included 168 symptomatic female KOA patients with persistent joint effusion. Results Overall, our analyses showed that associations with KOA outcomes were of higher magnitude within the KOIP groups than for the overall patient series (all p-values < 1.30e−16) and that several of the cytokines showed a KOIP-specific behaviour regarding their associations with KOA outcomes. Conclusion Our study adds further evidence supporting KOA as a multifaceted syndrome composed of multiple phenotypes with differing pathophysiological pathways, providing an explanation for inconsistencies between previous studies focussed on the role of cytokines in OA and the lack of translational results to date. Our findings also highlight the potential clinical benefits of accurately phenotyping KOA patients, including improved patient stratification, tailored therapies, and the discovery of novel treatments. |
| first_indexed | 2024-03-08T14:14:35Z |
| format | Article |
| id | doaj.art-dba1ce8853a6421f81c091221400508a |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-03-08T14:14:35Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-dba1ce8853a6421f81c091221400508a2024-01-14T12:31:31ZengBMCArthritis Research & Therapy1478-63622024-01-0126111210.1186/s13075-023-03244-ySpecific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotypingJoan Calvet0Antoni Berenguer-Llergo1Cristóbal Orellana2María García-Manrique3Menna Rusiñol4Silvia Garcia-Cirera5Maria Llop6Marta Arévalo7Alba Garcia-Pinilla8Carlos Galisteo9Cristina Aymerich10Rafael Gómez11Alejandra Serrano12Anna Carreras13Jordi Gratacós14Department of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariDepartment of Rheumatology, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, c/Parc Taulí s/n, edifici VII CentenariAbstract Background Despite existing extensive literature, a comprehensive and clinically relevant classification system for osteoarthritis (OA) has yet to be established. In this study, we aimed to further characterize four knee OA (KOA) inflammatory phenotypes (KOIP) recently proposed by our group, by identifying the inflammatory factors associated with KOA severity and progression in a phenotype-specific manner. Methods We performed an analysis within each of the previously defined four KOIP groups, to assess the association between KOA severity and progression and a panel of 13 cytokines evaluated in the plasma and synovial fluid of our cohort’s patients. The cohort included 168 symptomatic female KOA patients with persistent joint effusion. Results Overall, our analyses showed that associations with KOA outcomes were of higher magnitude within the KOIP groups than for the overall patient series (all p-values < 1.30e−16) and that several of the cytokines showed a KOIP-specific behaviour regarding their associations with KOA outcomes. Conclusion Our study adds further evidence supporting KOA as a multifaceted syndrome composed of multiple phenotypes with differing pathophysiological pathways, providing an explanation for inconsistencies between previous studies focussed on the role of cytokines in OA and the lack of translational results to date. Our findings also highlight the potential clinical benefits of accurately phenotyping KOA patients, including improved patient stratification, tailored therapies, and the discovery of novel treatments.https://doi.org/10.1186/s13075-023-03244-yKnee osteoarthritisCytokinesPhenotypeInflammationClinical severityRadiographic progression |
| spellingShingle | Joan Calvet Antoni Berenguer-Llergo Cristóbal Orellana María García-Manrique Menna Rusiñol Silvia Garcia-Cirera Maria Llop Marta Arévalo Alba Garcia-Pinilla Carlos Galisteo Cristina Aymerich Rafael Gómez Alejandra Serrano Anna Carreras Jordi Gratacós Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping Arthritis Research & Therapy Knee osteoarthritis Cytokines Phenotype Inflammation Clinical severity Radiographic progression |
| title | Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping |
| title_full | Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping |
| title_fullStr | Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping |
| title_full_unstemmed | Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping |
| title_short | Specific-cytokine associations with outcomes in knee osteoarthritis subgroups: breaking down disease heterogeneity with phenotyping |
| title_sort | specific cytokine associations with outcomes in knee osteoarthritis subgroups breaking down disease heterogeneity with phenotyping |
| topic | Knee osteoarthritis Cytokines Phenotype Inflammation Clinical severity Radiographic progression |
| url | https://doi.org/10.1186/s13075-023-03244-y |
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