Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice
Severe acute pancreatitis (SAP) is a fatal inflammation with no effective treatment. Salidroside, a monomer isolated from the traditional Chinese medicine Rhodiola, has been shown cytoprotective roles in many inflammation-related diseases. However, whether salidroside plays a protective role in an a...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622002493 |
| _version_ | 1811335984522985472 |
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| author | Cong-Cong Chen Yi-Hong Wang Rong-Yue Sun Xin-Yu Lu Yu-Peng Xu Yong-qiang Wang Jiang-Yuan Li Hong-Wei Wang Ke-Wei Chen |
| author_facet | Cong-Cong Chen Yi-Hong Wang Rong-Yue Sun Xin-Yu Lu Yu-Peng Xu Yong-qiang Wang Jiang-Yuan Li Hong-Wei Wang Ke-Wei Chen |
| author_sort | Cong-Cong Chen |
| collection | DOAJ |
| description | Severe acute pancreatitis (SAP) is a fatal inflammation with no effective treatment. Salidroside, a monomer isolated from the traditional Chinese medicine Rhodiola, has been shown cytoprotective roles in many inflammation-related diseases. However, whether salidroside plays a protective role in an acute inflammation like SAP in mice is unknown. In this study, we aimed to investigate the molecular mechanism underlying the pancreatic protection of salidroside. The results showed that salidroside attenuated caerulein with the LPS-induced pancreatic injury in a mouse model of SAP. Also, we found that salidroside ameliorated oxidative stress and inflammation responses in SAP mice. Furthermore, SAP mice treated with salidroside were associated with higher phosphorylation levels of Nrf2 and less nuclear accumulation of NF-κB p65. We further found that depletion of Nrf2 weakened the protective effect of salidroside in SAP mice. Collectively, salidroside mediated anti-oxidant stress and anti-inflammation in SAP mice partially through the Nrf2/NF-κB p65 pathway. |
| first_indexed | 2024-04-13T17:32:32Z |
| format | Article |
| id | doaj.art-dba267d0747a486dbf5a7e1c80435a3e |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-13T17:32:32Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-dba267d0747a486dbf5a7e1c80435a3e2022-12-22T02:37:31ZengElsevierJournal of Functional Foods1756-46462022-09-0196105179Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in miceCong-Cong Chen0Yi-Hong Wang1Rong-Yue Sun2Xin-Yu Lu3Yu-Peng Xu4Yong-qiang Wang5Jiang-Yuan Li6Hong-Wei Wang7Ke-Wei Chen8Department of Pharmacy, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaThe First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaThe First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaKey Laboratory of Diagnosis and Treatment of Severe Hepato‐Pancreatic Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaThe First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaKey Laboratory of Diagnosis and Treatment of Severe Hepato‐Pancreatic Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Corresponding authors.Department of Plastic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Corresponding authors.Severe acute pancreatitis (SAP) is a fatal inflammation with no effective treatment. Salidroside, a monomer isolated from the traditional Chinese medicine Rhodiola, has been shown cytoprotective roles in many inflammation-related diseases. However, whether salidroside plays a protective role in an acute inflammation like SAP in mice is unknown. In this study, we aimed to investigate the molecular mechanism underlying the pancreatic protection of salidroside. The results showed that salidroside attenuated caerulein with the LPS-induced pancreatic injury in a mouse model of SAP. Also, we found that salidroside ameliorated oxidative stress and inflammation responses in SAP mice. Furthermore, SAP mice treated with salidroside were associated with higher phosphorylation levels of Nrf2 and less nuclear accumulation of NF-κB p65. We further found that depletion of Nrf2 weakened the protective effect of salidroside in SAP mice. Collectively, salidroside mediated anti-oxidant stress and anti-inflammation in SAP mice partially through the Nrf2/NF-κB p65 pathway.http://www.sciencedirect.com/science/article/pii/S1756464622002493SalidrosideSevere acute pancreatitisNrf2NF-κB |
| spellingShingle | Cong-Cong Chen Yi-Hong Wang Rong-Yue Sun Xin-Yu Lu Yu-Peng Xu Yong-qiang Wang Jiang-Yuan Li Hong-Wei Wang Ke-Wei Chen Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice Journal of Functional Foods Salidroside Severe acute pancreatitis Nrf2 NF-κB |
| title | Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice |
| title_full | Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice |
| title_fullStr | Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice |
| title_full_unstemmed | Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice |
| title_short | Salidroside protects against caerulein with the LPS-induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice |
| title_sort | salidroside protects against caerulein with the lps induced severe acute pancreatitis through suppression of oxidative stress and inflammation in mice |
| topic | Salidroside Severe acute pancreatitis Nrf2 NF-κB |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622002493 |
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