The phenomenon of RNA interference in oncology: advances, problems and perspectives
Review describes the phenomenon of RNA interference – the recently discovered biological mechanism of the negative regulation of gene expression. The mechanism is based on the block of the translation and/or degradation of messenger RNA under short non-coding RNA, among them: microRNA and small inte...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2016-09-01
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| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/66 |
| _version_ | 1797759419582251008 |
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| author | O. E. Andreeva M. A. Krasil’nikov |
| author_facet | O. E. Andreeva M. A. Krasil’nikov |
| author_sort | O. E. Andreeva |
| collection | DOAJ |
| description | Review describes the phenomenon of RNA interference – the recently discovered biological mechanism of the negative regulation of gene expression. The mechanism is based on the block of the translation and/or degradation of messenger RNA under short non-coding RNA, among them: microRNA and small interfering RNA. The paper reviews the molecular processes of the formation of small RNA, the mechanism of their action and the feasibility of small RNA implementation in the anti-tumor therapy. Specially, we analyze the approaches to in vivo delivery of small RNA, in particular – the liposome and exosome constructs, and perspectives of the involvement of such constructs in the cancer treatment. |
| first_indexed | 2024-03-12T18:43:11Z |
| format | Article |
| id | doaj.art-dba27a9ff4cf4c5e9d857ad78f127f2c |
| institution | Directory Open Access Journal |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| last_indexed | 2024-03-12T18:43:11Z |
| publishDate | 2016-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj.art-dba27a9ff4cf4c5e9d857ad78f127f2c2023-08-02T07:48:05ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872016-09-013381510.17650/2313-805X-2016-3-3-08-1562The phenomenon of RNA interference in oncology: advances, problems and perspectivesO. E. Andreeva0M. A. Krasil’nikov1Научно-исследовательский институт канцерогенеза ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России; Россия, 115478, Москва, Каширское шоссе, 24Научно-исследовательский институт канцерогенеза ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России; Россия, 115478, Москва, Каширское шоссе, 24Review describes the phenomenon of RNA interference – the recently discovered biological mechanism of the negative regulation of gene expression. The mechanism is based on the block of the translation and/or degradation of messenger RNA under short non-coding RNA, among them: microRNA and small interfering RNA. The paper reviews the molecular processes of the formation of small RNA, the mechanism of their action and the feasibility of small RNA implementation in the anti-tumor therapy. Specially, we analyze the approaches to in vivo delivery of small RNA, in particular – the liposome and exosome constructs, and perspectives of the involvement of such constructs in the cancer treatment.https://umo.abvpress.ru/jour/article/view/66рнк-интерференциязлокачественная опухольмикрорнккороткие интерферирующие рнкрнк-доставкалипосомаэкзосома |
| spellingShingle | O. E. Andreeva M. A. Krasil’nikov The phenomenon of RNA interference in oncology: advances, problems and perspectives Успехи молекулярной онкологии рнк-интерференция злокачественная опухоль микрорнк короткие интерферирующие рнк рнк-доставка липосома экзосома |
| title | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_full | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_fullStr | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_full_unstemmed | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_short | The phenomenon of RNA interference in oncology: advances, problems and perspectives |
| title_sort | phenomenon of rna interference in oncology advances problems and perspectives |
| topic | рнк-интерференция злокачественная опухоль микрорнк короткие интерферирующие рнк рнк-доставка липосома экзосома |
| url | https://umo.abvpress.ru/jour/article/view/66 |
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