An endogenous lentivirus in the germline of a rodent
Abstract Lentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike many other retrovirus genera, lentiviruses have only rarely been incorporated into the mammalian germline. However, a small number of endogenous retrovirus (ERV) lineages...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Retrovirology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12977-022-00615-2 |
| _version_ | 1797977299303268352 |
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| author | Roziah Kambol Anna Gatseva Robert J. Gifford |
| author_facet | Roziah Kambol Anna Gatseva Robert J. Gifford |
| author_sort | Roziah Kambol |
| collection | DOAJ |
| description | Abstract Lentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike many other retrovirus genera, lentiviruses have only rarely been incorporated into the mammalian germline. However, a small number of endogenous retrovirus (ERV) lineages have been identified, and these rare genomic “fossils” can provide crucial insights into the long-term history of lentivirus evolution. Here, we describe a previously unreported endogenous lentivirus lineage in the genome of the South African springhare (Pedetes capensis), demonstrating that the host range of lentiviruses has historically extended to rodents (order Rodentia). Furthermore, through comparative and phylogenetic analysis of lentivirus and ERV genomes, considering the biogeographic and ecological characteristics of host species, we reveal broader insights into the long-term evolutionary history of the genus. |
| first_indexed | 2024-04-11T05:04:41Z |
| format | Article |
| id | doaj.art-dba44e2d82df42de98763743164f1d42 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-04-11T05:04:41Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-dba44e2d82df42de98763743164f1d422022-12-25T12:27:39ZengBMCRetrovirology1742-46902022-12-011911810.1186/s12977-022-00615-2An endogenous lentivirus in the germline of a rodentRoziah Kambol0Anna Gatseva1Robert J. Gifford2School of Biological Sciences, Faculty of Applied Sciences, University Teknologi MARAMRC-University of Glasgow Centre for Virus ResearchMRC-University of Glasgow Centre for Virus ResearchAbstract Lentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike many other retrovirus genera, lentiviruses have only rarely been incorporated into the mammalian germline. However, a small number of endogenous retrovirus (ERV) lineages have been identified, and these rare genomic “fossils” can provide crucial insights into the long-term history of lentivirus evolution. Here, we describe a previously unreported endogenous lentivirus lineage in the genome of the South African springhare (Pedetes capensis), demonstrating that the host range of lentiviruses has historically extended to rodents (order Rodentia). Furthermore, through comparative and phylogenetic analysis of lentivirus and ERV genomes, considering the biogeographic and ecological characteristics of host species, we reveal broader insights into the long-term evolutionary history of the genus.https://doi.org/10.1186/s12977-022-00615-2RetrovirusLentivirusEvolutionEcologyEndogenous retrovirusPaleovirology |
| spellingShingle | Roziah Kambol Anna Gatseva Robert J. Gifford An endogenous lentivirus in the germline of a rodent Retrovirology Retrovirus Lentivirus Evolution Ecology Endogenous retrovirus Paleovirology |
| title | An endogenous lentivirus in the germline of a rodent |
| title_full | An endogenous lentivirus in the germline of a rodent |
| title_fullStr | An endogenous lentivirus in the germline of a rodent |
| title_full_unstemmed | An endogenous lentivirus in the germline of a rodent |
| title_short | An endogenous lentivirus in the germline of a rodent |
| title_sort | endogenous lentivirus in the germline of a rodent |
| topic | Retrovirus Lentivirus Evolution Ecology Endogenous retrovirus Paleovirology |
| url | https://doi.org/10.1186/s12977-022-00615-2 |
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