Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ROCK pathway

Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ROCK pathway

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease without early diagnostic and specific therapeutic approaches. Podocyte apoptosis and loss play important roles in the pathological process of DKD. This study aimed to explore whether urinary exosomes from type 2 diabetes pat...

Descrición completa

Detalles Bibliográficos
Main Authors:	Lulu Han, Shenghai Wang, Juan Li, Lulu Zhao, Hong Zhou
Formato:	Artigo
Idioma:	English
Publicado:	Elsevier 2023-12-01
Series:	Experimental and Molecular Pathology
Subjects:	Diabetic kidney disease Urinary exosomes MicroRNA-145-5p Srgap2 ROCK Podocyte apoptosis
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S001448002300028X

Títulos similares

Impact of klotho on the expression of SRGAP2a in podocytes in diabetic nephropathy
por: Donghua Jin, et al.
Publicado: (2022-04-01)

srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability
por: Alba Lopez Rioja, et al.
Publicado: (2022-03-01)

Research progress on exosomes in podocyte injury associated with diabetic kidney disease
por: Jiao Li, et al.
Publicado: (2023-03-01)

Expression profile of microrna-145 in urothelial bladder cancer
por: Nelson Dip, et al.
Publicado: (2013-01-01)

Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL
por: Qiaoyun Wu, et al.
Publicado: (2023-05-01)

Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells
por: Jie Gao, et al.
Publicado: (2016-04-01)

microRNA in Extracellular Vesicles Released by Damaged Podocytes Promote Apoptosis of Renal Tubular Epithelial Cells
por: Jin Seok Jeon, et al.
Publicado: (2020-06-01)

Circulating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure
por: Ming Zhang, et al.
Publicado: (2017-01-01)

Quantification of urinary podocyte‐derived migrasomes for the diagnosis of kidney disease
por: Rong Yang, et al.
Publicado: (2024-06-01)

Effect of Sirt1 on high glucose-induced exosome release from podocytes
por: DING Lin, ZHOU Yan, LIU Shanshan, LIU Nanchi, MA Ruixia
Publicado: (2024-02-01)

The value of urinary exosomal microRNA‐21 in the early diagnosis and prognosis of bladder cancer
por: Fu‐Kan Yang, et al.
Publicado: (2024-07-01)

Podocyte Pathology and Nephropathy
por: Barbara eLewko, et al.
Publicado: (2015-09-01)

Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation
por: Lei Zhang, et al.
Publicado: (2017-10-01)

Use and isolation of urinary exosomes as biomarkers for diabetic nephropathy
por: Luca eMusante, et al.
Publicado: (2014-09-01)

Exosomes secreted by podocytes regulate the differentiation of Th17/Treg cells in idiopathic nephrotic syndrome
por: Yang Jia, et al.
Publicado: (2024-09-01)

Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage
por: Qian Li, et al.
Publicado: (2023-10-01)

A YAP/TAZ–ARHGAP29–RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin Adhesions
por: Manuel Rogg, et al.
Publicado: (2023-07-01)

Urinary exosome miR-146a is a potential marker of albuminuria in essential hypertension
por: Javier Perez-Hernandez, et al.
Publicado: (2018-08-01)

Serial selection for invasiveness increases expression of miR-143/miR-145 in glioblastoma cell lines
por: Koo Sunwoo, et al.
Publicado: (2012-04-01)

Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes
por: Guangbi Li, et al.
Publicado: (2021-07-01)

Diagnostic value of miR-145 and its regulatory role in macrophage immune response in tuberculosis
por: Yinghui Fu, et al.

A Tight Control of Non-Canonical TGF-β Pathways and MicroRNAs Downregulates Nephronectin in Podocytes
por: Nina Sopel, et al.
Publicado: (2022-01-01)

Urinary podocyte microparticles are associated with disease activity and renal injury in systemic lupus erythematosus
por: Jian Lu, et al.
Publicado: (2019-08-01)

Relationship between cluster miR-143/145 micro-RNAs with oncogenesis: tissue and cellular context
por: E. N. Voropaeva, et al.
Publicado: (2023-06-01)

Bone marrow mesenchymal stem cells-derived exosomal miR-145-5p reduced non-small cell lung cancer cell progression by targeting SOX9
por: Wu Yan, et al.
Publicado: (2024-07-01)

Urinary microRNA in Diabetic Kidney Disease: A Literature Review
por: Chin-Chan Lee, et al.
Publicado: (2023-02-01)

MicroRNA-145 is involved in endothelial cell dysfunction and acts as a promising biomarker of acute coronary syndrome
por: Shanshan Wu, et al.
Publicado: (2020-03-01)

Quantitative Analysis of Mitochondrial DNA Heteroplasmy in Urinary Podocytes of Myoclonus Epilepsy With Ragged-Red Fibers Syndrome
por: Miwa Goto, et al.
Publicado: (2023-12-01)

Prognostic utility of microRNA-145 and CD 133 in oral squamous cell carcinoma: A pilot study from Northern India
por: Alok Singh, et al.
Publicado: (2023-03-01)

Exosomal MicroRNAs as Biomarkers in Allergic Asthma
por: Sahar Rostami Hir, et al.
Publicado: (2021-04-01)

Podocyte-specific deletion of miR-146a increases podocyte injury and diabetic kidney disease
por: Xiaobo Li, et al.
Publicado: (2022-08-01)

Higher Urine Exosomal miR-193a Is Associated With a Higher Probability of Primary Focal Segmental Glomerulosclerosis and an Increased Risk of Poor Prognosis Among Children With Nephrotic Syndrome
por: Lixia Wang, et al.
Publicado: (2021-10-01)

microRNA-145-5p Inhibits Migration, Invasion, and Metastasis in Hepatocellular Carcinoma by Inhibiting ARF6
por: Wang S, et al.
Publicado: (2021-04-01)

Synergistic effects of Cassia fistula extract combination with cisplatin on the regulation of microRNA-145 and gene expression in colon cancer cell line SW480
por: Rana Talib Al-Muswie, et al.
Publicado: (2023-01-01)

Urinary Exosomal miRNAs as biomarkers of bladder Cancer and experimental verification of mechanism of miR-93-5p in bladder Cancer
por: Hao Lin, et al.
Publicado: (2021-12-01)

Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling [Corrigendum]
por: Yu J, et al.
Publicado: (2020-03-01)

Exosomes and microRNAs as mediators of the exercise
por: Haoyuan Li, et al.
Publicado: (2025-01-01)

Exosomal microRNAs in hepatocellular carcinoma
por: Chenbin Liu, et al.
Publicado: (2021-05-01)

Mesenchymal stem-cell-derived exosomal miR-145 inhibits atherosclerosis by targeting JAM-A
por: Wenzhi Yang, et al.
Publicado: (2021-03-01)

The functional role of exosome microRNAs in lung cancer
por: Li Jia, et al.
Publicado: (2017-09-01)