MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease
Dorsal stream, which has a neuronal connection with dorsolateral prefrontal cortex (DLPFC), is known to be responsible for detection of motion including optic flow perception. Using magnetoencephalography (MEG), this study aimed to examine neural responses to optic flow stimuli with looming motion i...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570504/?tool=EBI |
| _version_ | 1818433335696818176 |
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| author | Moeko Noguchi-Shinohara Masato Koike Hirofumi Morise Kiwamu Kudo Shoko Tsuchimine Junji Komatsu Chiemi Abe Sachiko Kitagawa Yoshihisa Ikeda Masahito Yamada |
| author_facet | Moeko Noguchi-Shinohara Masato Koike Hirofumi Morise Kiwamu Kudo Shoko Tsuchimine Junji Komatsu Chiemi Abe Sachiko Kitagawa Yoshihisa Ikeda Masahito Yamada |
| author_sort | Moeko Noguchi-Shinohara |
| collection | DOAJ |
| description | Dorsal stream, which has a neuronal connection with dorsolateral prefrontal cortex (DLPFC), is known to be responsible for detection of motion including optic flow perception. Using magnetoencephalography (MEG), this study aimed to examine neural responses to optic flow stimuli with looming motion in the DLPFC in patients with mild cognitive impairment due to Alzheimer’s disease (AD-MCI) compared with cognitively unimpaired participants (CU). We analyzed the neural responses by evaluating maximum source-localized power for the AD-MCI group (n = 11) and CU (n = 20), focusing on six regions of interest (ROIs) that form the DLPFC: right and left dorsal Brodmann area 9/46 (A9/46d), Brodmann area 46 (A46) and ventral Brodmann area 9/46 (A9/46v). We found significant differences in the maximum power between the groups in the left A46 and A9/46v. Moreover, in the left A9/46v, the maximum power significantly correlated with the Wechsler Memory Scale-Revised general memory score and delayed recall score. The maximum power in the left A9/46v also revealed high performance in AD-MCI versus CU classification with the area under the ROC curve of 0.90. This study demonstrated that MEG during the optic flow task can be useful in discriminating AD-MCI from CU. |
| first_indexed | 2024-12-14T16:19:28Z |
| format | Article |
| id | doaj.art-dba78a8fd109422991e91cdef257d239 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T16:19:28Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dba78a8fd109422991e91cdef257d2392022-12-21T22:54:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s diseaseMoeko Noguchi-ShinoharaMasato KoikeHirofumi MoriseKiwamu KudoShoko TsuchimineJunji KomatsuChiemi AbeSachiko KitagawaYoshihisa IkedaMasahito YamadaDorsal stream, which has a neuronal connection with dorsolateral prefrontal cortex (DLPFC), is known to be responsible for detection of motion including optic flow perception. Using magnetoencephalography (MEG), this study aimed to examine neural responses to optic flow stimuli with looming motion in the DLPFC in patients with mild cognitive impairment due to Alzheimer’s disease (AD-MCI) compared with cognitively unimpaired participants (CU). We analyzed the neural responses by evaluating maximum source-localized power for the AD-MCI group (n = 11) and CU (n = 20), focusing on six regions of interest (ROIs) that form the DLPFC: right and left dorsal Brodmann area 9/46 (A9/46d), Brodmann area 46 (A46) and ventral Brodmann area 9/46 (A9/46v). We found significant differences in the maximum power between the groups in the left A46 and A9/46v. Moreover, in the left A9/46v, the maximum power significantly correlated with the Wechsler Memory Scale-Revised general memory score and delayed recall score. The maximum power in the left A9/46v also revealed high performance in AD-MCI versus CU classification with the area under the ROC curve of 0.90. This study demonstrated that MEG during the optic flow task can be useful in discriminating AD-MCI from CU.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570504/?tool=EBI |
| spellingShingle | Moeko Noguchi-Shinohara Masato Koike Hirofumi Morise Kiwamu Kudo Shoko Tsuchimine Junji Komatsu Chiemi Abe Sachiko Kitagawa Yoshihisa Ikeda Masahito Yamada MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease PLoS ONE |
| title | MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease |
| title_full | MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease |
| title_fullStr | MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease |
| title_full_unstemmed | MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease |
| title_short | MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease |
| title_sort | meg activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to alzheimer s disease |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570504/?tool=EBI |
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