Retinal structural changes in patients with Alzheimer's disease
Background: Retinal disorders in patients with Alzheimer's disease (AD) are given special attention. Purpose: To identify optical coherence tomography (OCT)-based retinal structural changes in patients with mild or moderate AD. Materials and Methods: Forty-five AD patients (88 eyes; age,...
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| Format: | Article |
| Language: | English |
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Ukrainian Society of Ophthalmologists
2019-08-01
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| Series: | Journal of Ophthalmology |
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| Online Access: | https://www.ozhurnal.com/en/archive/2019/4/7-fulltext |
| _version_ | 1827576809040904192 |
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| author | R.N. Guliyeva |
| author_facet | R.N. Guliyeva |
| author_sort | R.N. Guliyeva |
| collection | DOAJ |
| description | Background: Retinal disorders in patients with Alzheimer's disease (AD) are given special attention.
Purpose: To identify optical coherence tomography (OCT)-based retinal structural changes in patients with mild or moderate AD.
Materials and Methods: Forty-five AD patients (88 eyes; age, 66.2 ± 3.44 years) with mild or moderate cognitive impairments were involved into the study. All subjects underwent a conventional eye examination and OCT measurements. For Cirrus HD-OCT imaging, the Macular Cube 512 ? 128 Combo protocol was used. The RNFL, retinal ganglion cell layer (RGCL), and internal plexiform layer (IPL) thicknesses were determined using RNFL and ganglion cell complex (GCC) protocols.
Results: Compared with controls, patients with AD had 53.2% lower Mini Mental State Examination (MMSE) scores (p < 0.05). In addition, RNFL thicknesses in the temporal, superior and inferior quadrants in patients with AD were significantly (31.4%, 21.8% and 33.1%, respectively; p < 0.05) thinner compared to controls. Moreover, compared to controls, focal loss volume (FLV) and global loss volume (GLV) of GCC in AD patients were 1.7 times (p < 0.05) and 2.8 times (p < 0.01), respectively, increased, whereas central macular thickness, overall macular cube volume and average macular cube thickness were 14%, 17.8% and 3.5% decreased.
Conclusion: Our findings confirm the reports of changes in the retinal structure in patients with mild or moderate AD, particularly, the decreased GCC thickness and increased GCC FLV and GLV. |
| first_indexed | 2024-03-08T21:17:49Z |
| format | Article |
| id | doaj.art-dba7c568d3d74ab281d79783226b6002 |
| institution | Directory Open Access Journal |
| issn | 2412-8740 |
| language | English |
| last_indexed | 2024-03-08T21:17:49Z |
| publishDate | 2019-08-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-dba7c568d3d74ab281d79783226b60022023-12-21T14:46:55ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402019-08-014333710.31288/oftalmolzh201943337Retinal structural changes in patients with Alzheimer's disease R.N. Guliyeva0Acad. Z. Aliyeva National Ophthalmology CenterBackground: Retinal disorders in patients with Alzheimer's disease (AD) are given special attention. Purpose: To identify optical coherence tomography (OCT)-based retinal structural changes in patients with mild or moderate AD. Materials and Methods: Forty-five AD patients (88 eyes; age, 66.2 ± 3.44 years) with mild or moderate cognitive impairments were involved into the study. All subjects underwent a conventional eye examination and OCT measurements. For Cirrus HD-OCT imaging, the Macular Cube 512 ? 128 Combo protocol was used. The RNFL, retinal ganglion cell layer (RGCL), and internal plexiform layer (IPL) thicknesses were determined using RNFL and ganglion cell complex (GCC) protocols. Results: Compared with controls, patients with AD had 53.2% lower Mini Mental State Examination (MMSE) scores (p < 0.05). In addition, RNFL thicknesses in the temporal, superior and inferior quadrants in patients with AD were significantly (31.4%, 21.8% and 33.1%, respectively; p < 0.05) thinner compared to controls. Moreover, compared to controls, focal loss volume (FLV) and global loss volume (GLV) of GCC in AD patients were 1.7 times (p < 0.05) and 2.8 times (p < 0.01), respectively, increased, whereas central macular thickness, overall macular cube volume and average macular cube thickness were 14%, 17.8% and 3.5% decreased. Conclusion: Our findings confirm the reports of changes in the retinal structure in patients with mild or moderate AD, particularly, the decreased GCC thickness and increased GCC FLV and GLV.https://www.ozhurnal.com/en/archive/2019/4/7-fulltextretinaalzheimer's diseasernflthicknessgccmacular cube |
| spellingShingle | R.N. Guliyeva Retinal structural changes in patients with Alzheimer's disease Journal of Ophthalmology retina alzheimer's disease rnfl thickness gcc macular cube |
| title | Retinal structural changes in patients with Alzheimer's disease |
| title_full | Retinal structural changes in patients with Alzheimer's disease |
| title_fullStr | Retinal structural changes in patients with Alzheimer's disease |
| title_full_unstemmed | Retinal structural changes in patients with Alzheimer's disease |
| title_short | Retinal structural changes in patients with Alzheimer's disease |
| title_sort | retinal structural changes in patients with alzheimer s disease |
| topic | retina alzheimer's disease rnfl thickness gcc macular cube |
| url | https://www.ozhurnal.com/en/archive/2019/4/7-fulltext |
| work_keys_str_mv | AT rnguliyeva retinalstructuralchangesinpatientswithalzheimersdisease |