Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults
Aims: Aging, obesity, and type 2 diabetes mellitus (T2DM) form a metabolic disease continuum that has a continuously increasing prevalence. Lipidomics explains the complex interactions between lipid metabolism and metabolic diseases. We aimed to systematically investigate the plasma lipidome changes...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-11-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/12/12/EC-23-0212.xml |
| _version_ | 1797450803961659392 |
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| author | Feifei Shao Xinxin Hu Jiayu Li Bona Bai Limin Tian |
| author_facet | Feifei Shao Xinxin Hu Jiayu Li Bona Bai Limin Tian |
| author_sort | Feifei Shao |
| collection | DOAJ |
| description | Aims: Aging, obesity, and type 2 diabetes mellitus (T2DM) form a metabolic disease continuum that has a continuously increasing prevalence. Lipidomics explains the complex interactions between lipid metabolism and metabolic diseases. We aimed to systematically investigate the plasma lipidome changes induced by newly diagnosed impaired glucose tolerance (IGT) and T2DM in overweight/obese elderly individuals and to identify potential biomarkers to differentiate between the IGT, T2DM, and control groups.
Methods: Plasma samples from 148 overweight/obese elderly individuals, including 52 patients with IGT, 47 patients with T2DM, and 49 euglycemic controls, were analyzed using a high-coverage nontargeted absolute quantitative lipidomics approach.
Results: We quantified 1840 lipids from thirty-eight classes and seven lipid categories. Among overweight/obese elderly individuals, the lipidomic profiles of IGT and T2DM patients were significantly different from those of controls, while they were similar in the IGT and T2DM groups. The concentrations of diglycerides, triglycerides, phosphatidylcholines, and ceramides were obviously altered in the IGT and T2DM groups. Particularly, IGT and T2DM induced the accumulation of triglycerides with longer carbon atom numbers (C44–50) and saturated or lower double bond numbers (n (C=C) = 0–2). Furthermore, a total of 17 potential lipidic biomarkers were identified to successfully differentiate between the IGT, T2DM, and control groups.
Conclusions: In overweight/obese elderly patients, IGT and T2DM induced apparent lipidome-wide changes. This study’s results may contribute to explaining the complex dysfunctional lipid metabolism in aging, obesity, and diabetes. |
| first_indexed | 2024-03-09T14:44:55Z |
| format | Article |
| id | doaj.art-dba8a420aefb4a45b7e62a7873c65c0d |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-03-09T14:44:55Z |
| publishDate | 2023-11-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-dba8a420aefb4a45b7e62a7873c65c0d2023-11-27T09:53:46ZengBioscientificaEndocrine Connections2049-36142023-11-011212114https://doi.org/10.1530/EC-23-0212Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adultsFeifei Shao0Xinxin Hu1Jiayu Li2Bona Bai3Limin Tian4Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, Gansu, China; Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, Gansu, China; Clinical Research Center for Metabolic Disease, Gansu Province, Lanzhou, Gansu, China; The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China Aims: Aging, obesity, and type 2 diabetes mellitus (T2DM) form a metabolic disease continuum that has a continuously increasing prevalence. Lipidomics explains the complex interactions between lipid metabolism and metabolic diseases. We aimed to systematically investigate the plasma lipidome changes induced by newly diagnosed impaired glucose tolerance (IGT) and T2DM in overweight/obese elderly individuals and to identify potential biomarkers to differentiate between the IGT, T2DM, and control groups. Methods: Plasma samples from 148 overweight/obese elderly individuals, including 52 patients with IGT, 47 patients with T2DM, and 49 euglycemic controls, were analyzed using a high-coverage nontargeted absolute quantitative lipidomics approach. Results: We quantified 1840 lipids from thirty-eight classes and seven lipid categories. Among overweight/obese elderly individuals, the lipidomic profiles of IGT and T2DM patients were significantly different from those of controls, while they were similar in the IGT and T2DM groups. The concentrations of diglycerides, triglycerides, phosphatidylcholines, and ceramides were obviously altered in the IGT and T2DM groups. Particularly, IGT and T2DM induced the accumulation of triglycerides with longer carbon atom numbers (C44–50) and saturated or lower double bond numbers (n (C=C) = 0–2). Furthermore, a total of 17 potential lipidic biomarkers were identified to successfully differentiate between the IGT, T2DM, and control groups. Conclusions: In overweight/obese elderly patients, IGT and T2DM induced apparent lipidome-wide changes. This study’s results may contribute to explaining the complex dysfunctional lipid metabolism in aging, obesity, and diabetes.https://ec.bioscientifica.com/view/journals/ec/12/12/EC-23-0212.xmlagingobesityimpaired glucose tolerancetype 2 diabetes mellituslipidomics |
| spellingShingle | Feifei Shao Xinxin Hu Jiayu Li Bona Bai Limin Tian Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults Endocrine Connections aging obesity impaired glucose tolerance type 2 diabetes mellitus lipidomics |
| title | Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults |
| title_full | Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults |
| title_fullStr | Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults |
| title_full_unstemmed | Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults |
| title_short | Lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults |
| title_sort | lipidomics analysis of impaired glucose tolerance and type 2 diabetes mellitus in overweight or obese elderly adults |
| topic | aging obesity impaired glucose tolerance type 2 diabetes mellitus lipidomics |
| url | https://ec.bioscientifica.com/view/journals/ec/12/12/EC-23-0212.xml |
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