Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair
A combined approach in spinal cord injury (SCI) therapy is the modulation of the cellular and molecular processes involved in glial scarring. Aldaynoglial cells are neural cell precursors with a high capacity to differentiate into neurons, promote axonal growth, wrapping and myelination of resident...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=7;spage=1043;epage=1045;aulast=Doncel-Pérez |
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| author | Ernesto Doncel-Pérez Manuel Nieto-Sampedro |
| author_facet | Ernesto Doncel-Pérez Manuel Nieto-Sampedro |
| author_sort | Ernesto Doncel-Pérez |
| collection | DOAJ |
| description | A combined approach in spinal cord injury (SCI) therapy is the modulation of the cellular and molecular processes involved in glial scarring. Aldaynoglial cells are neural cell precursors with a high capacity to differentiate into neurons, promote axonal growth, wrapping and myelination of resident neurons. These important characteristics of aldaynoglia can be combined with specific inhibition of the RhoGTPase ac-tivity in astroglia and microglia that cause reduction of glial proliferation, retraction of glial cell processes and myelin production by oligodendrocytes. Previously we used experimental central nervous system (CNS) injury models, like spinal cord contusion and striatal lacunar infarction and observed that adminis-tration of RhoGTPase glycolipid inhibitor or aldaynoglial cells, respectively, produced a significant gain of functional recovery in treated animals. The combined therapy with neuro-regenerative properties strategy is highly desirable to treat SCI for functional potentiation of neurons and oligodendrocytes, resulting in better locomotor recovery. Here we suggest that treatment of spinal lesions with aldaynoglia from neu-rospheres plus local administration of a RhoGTPase inhibitor could have an additive effect and promote recovery from SCI. |
| first_indexed | 2024-12-14T11:28:22Z |
| format | Article |
| id | doaj.art-dba9da97698946288300c3f17b3048fb |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-14T11:28:22Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-dba9da97698946288300c3f17b3048fb2022-12-21T23:03:26ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742016-01-011171043104510.4103/1673-5374.187020Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repairErnesto Doncel-PérezManuel Nieto-SampedroA combined approach in spinal cord injury (SCI) therapy is the modulation of the cellular and molecular processes involved in glial scarring. Aldaynoglial cells are neural cell precursors with a high capacity to differentiate into neurons, promote axonal growth, wrapping and myelination of resident neurons. These important characteristics of aldaynoglia can be combined with specific inhibition of the RhoGTPase ac-tivity in astroglia and microglia that cause reduction of glial proliferation, retraction of glial cell processes and myelin production by oligodendrocytes. Previously we used experimental central nervous system (CNS) injury models, like spinal cord contusion and striatal lacunar infarction and observed that adminis-tration of RhoGTPase glycolipid inhibitor or aldaynoglial cells, respectively, produced a significant gain of functional recovery in treated animals. The combined therapy with neuro-regenerative properties strategy is highly desirable to treat SCI for functional potentiation of neurons and oligodendrocytes, resulting in better locomotor recovery. Here we suggest that treatment of spinal lesions with aldaynoglia from neu-rospheres plus local administration of a RhoGTPase inhibitor could have an additive effect and promote recovery from SCI.http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=7;spage=1043;epage=1045;aulast=Doncel-Pérezglial scar; astrocyte; microglia; neurospheres; aldaynoglia; axonal growth; myelination; glycoside inhibitor |
| spellingShingle | Ernesto Doncel-Pérez Manuel Nieto-Sampedro Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair Neural Regeneration Research glial scar; astrocyte; microglia; neurospheres; aldaynoglia; axonal growth; myelination; glycoside inhibitor |
| title | Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair |
| title_full | Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair |
| title_fullStr | Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair |
| title_full_unstemmed | Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair |
| title_short | Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair |
| title_sort | aldynoglia cells and modulation of rhogtpase activity as useful tools for spinal cord injury repair |
| topic | glial scar; astrocyte; microglia; neurospheres; aldaynoglia; axonal growth; myelination; glycoside inhibitor |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=7;spage=1043;epage=1045;aulast=Doncel-Pérez |
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