Tools of genomic medicine for clinical practice: The example of psychiatry
Most psychiatric disorders are moderate to highly heritable, often with different genetic architectures. Although genetic research in psychiatry has progressed, its findings, interpretation, and impact on clinical psychiatry are unknown to most mental healthcare professionals. This article addresses...
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| Format: | Article |
| Language: | English |
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Medwave Estudios Limitada
2023-07-01
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| Series: | Medwave |
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| Online Access: | https://www.medwave.cl/revisiones/revisiontemas/2708.html |
| _version_ | 1797754317372915712 |
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| author | Camila Vargas María Leonor Bustamante Trinidad Kahler Fernanda Vargas Ulises Ríos Angela Muñoz Francisca Opazo Marcelo Arancibia |
| author_facet | Camila Vargas María Leonor Bustamante Trinidad Kahler Fernanda Vargas Ulises Ríos Angela Muñoz Francisca Opazo Marcelo Arancibia |
| author_sort | Camila Vargas |
| collection | DOAJ |
| description | Most psychiatric disorders are moderate to highly heritable, often with different genetic architectures. Although genetic research in psychiatry has progressed, its findings, interpretation, and impact on clinical psychiatry are unknown to most mental healthcare professionals. This article addresses key genetic concepts to understand some clinical entities, emphasizing genetic terminology and types of mutations. Particularly, we describe the role of heritability in the early days of psychiatry genetic research, the most used study designs, and their main objectives. On the other hand, we review some genetic and genomic databases useful for clinical practice. These include Online Mendelian Inheritance in Man, ClinVar, Ensembl, and The Single Nucleotide Polymorphism Database. Finally, a clinical vignette is presented in which we can apply genomic medicine tools. Since the evidence in psychiatric genetics is based on studies carried out in European or North American ancestral populations, we must develop local studies to increase the knowledge and application of genomic medicine on underrepresented populations. |
| first_indexed | 2024-03-12T17:31:00Z |
| format | Article |
| id | doaj.art-dbab4bfbc47644cbb115dc8db3cf0200 |
| institution | Directory Open Access Journal |
| issn | 0717-6384 |
| language | English |
| last_indexed | 2024-03-12T17:31:00Z |
| publishDate | 2023-07-01 |
| publisher | Medwave Estudios Limitada |
| record_format | Article |
| series | Medwave |
| spelling | doaj.art-dbab4bfbc47644cbb115dc8db3cf02002023-08-04T20:43:29ZengMedwave Estudios LimitadaMedwave0717-63842023-07-012306e2708e270810.5867/medwave.2023.06.2708Tools of genomic medicine for clinical practice: The example of psychiatryCamila Vargas0https://orcid.org/0000-0002-4917-2124María Leonor Bustamante1https://orcid.org/0000-0001-9071-2463Trinidad Kahler2https://orcid.org/0000-0001-6298-8147Fernanda Vargas3https://orcid.org/0000-0001-9636-1422Ulises Ríos4https://orcid.org/0000-0001-6227-4451Angela Muñoz5https://orcid.org/0000-0002-2739-173XFrancisca Opazo6https://orcid.org/0000-0002-8878-1205Marcelo Arancibia7https://orcid.org/0000-0003-2239-6248Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Viña del Mar, ChileLaboratorio de Genética de Enfermedades Neuropsiquiátricas, Programa de Genética Humana, Instituto de Ciencias Biomédicas, Universidad de Chile, Independencia, ChileEscuela de Medicina, Facultad de Medicina, Universidad de Chile, Independencia, ChileFacultad de Ciencias, Universidad de Valparaíso, Valparaíso, ChileDepartamento de Psiquiatría, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Valparaíso, ChileEscuela de Medicina, Facultad de Medicina, Universidad de Chile, Independencia, ChileEscuela de Medicina, Facultad de Medicina, Universidad de Chile, Independencia, ChileDepartamento de Psiquiatría, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Valparaíso, ChileMost psychiatric disorders are moderate to highly heritable, often with different genetic architectures. Although genetic research in psychiatry has progressed, its findings, interpretation, and impact on clinical psychiatry are unknown to most mental healthcare professionals. This article addresses key genetic concepts to understand some clinical entities, emphasizing genetic terminology and types of mutations. Particularly, we describe the role of heritability in the early days of psychiatry genetic research, the most used study designs, and their main objectives. On the other hand, we review some genetic and genomic databases useful for clinical practice. These include Online Mendelian Inheritance in Man, ClinVar, Ensembl, and The Single Nucleotide Polymorphism Database. Finally, a clinical vignette is presented in which we can apply genomic medicine tools. Since the evidence in psychiatric genetics is based on studies carried out in European or North American ancestral populations, we must develop local studies to increase the knowledge and application of genomic medicine on underrepresented populations.https://www.medwave.cl/revisiones/revisiontemas/2708.htmlgeneticsgenomicsmental disorderspsychiatry |
| spellingShingle | Camila Vargas María Leonor Bustamante Trinidad Kahler Fernanda Vargas Ulises Ríos Angela Muñoz Francisca Opazo Marcelo Arancibia Tools of genomic medicine for clinical practice: The example of psychiatry Medwave genetics genomics mental disorders psychiatry |
| title | Tools of genomic medicine for clinical practice: The example of psychiatry |
| title_full | Tools of genomic medicine for clinical practice: The example of psychiatry |
| title_fullStr | Tools of genomic medicine for clinical practice: The example of psychiatry |
| title_full_unstemmed | Tools of genomic medicine for clinical practice: The example of psychiatry |
| title_short | Tools of genomic medicine for clinical practice: The example of psychiatry |
| title_sort | tools of genomic medicine for clinical practice the example of psychiatry |
| topic | genetics genomics mental disorders psychiatry |
| url | https://www.medwave.cl/revisiones/revisiontemas/2708.html |
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