The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors
Recent advancements in adoptive cell therapy (ACT) are opening up new frontiers for cancer immunotherapy. CAR T cells targeting CD19 have emerged as a remarkable T cell-based therapy for the successful treatment of certain types of leukemia and lymphomas. Despite these clinical successes, as well as...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-10-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1345833 |
| _version_ | 1797677578631249920 |
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| author | Ryan Zander Weiguo Cui |
| author_facet | Ryan Zander Weiguo Cui |
| author_sort | Ryan Zander |
| collection | DOAJ |
| description | Recent advancements in adoptive cell therapy (ACT) are opening up new frontiers for cancer immunotherapy. CAR T cells targeting CD19 have emerged as a remarkable T cell-based therapy for the successful treatment of certain types of leukemia and lymphomas. Despite these clinical successes, as well as significant breakthroughs in T cell engineering, the treatment of solid tumors with ACT remains a relentless challenge. Thus, the current consensus of the field is that an urgent need exists for the design of innovative approaches that can improve the efficacy of ACT in treating solid cancers while maintaining a high degree of reliability and safety. |
| first_indexed | 2024-03-11T22:47:18Z |
| format | Article |
| id | doaj.art-dbac7b7f476c48d9810cd86284f22935 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:47:18Z |
| publishDate | 2017-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-dbac7b7f476c48d9810cd86284f229352023-09-22T08:17:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-10-0113102269227110.1080/21645515.2017.13458331345833The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumorsRyan Zander0Weiguo Cui1Blood Center of Wisconsin, Milwaukee, WI, USABlood Center of Wisconsin, Milwaukee, WI, USARecent advancements in adoptive cell therapy (ACT) are opening up new frontiers for cancer immunotherapy. CAR T cells targeting CD19 have emerged as a remarkable T cell-based therapy for the successful treatment of certain types of leukemia and lymphomas. Despite these clinical successes, as well as significant breakthroughs in T cell engineering, the treatment of solid tumors with ACT remains a relentless challenge. Thus, the current consensus of the field is that an urgent need exists for the design of innovative approaches that can improve the efficacy of ACT in treating solid cancers while maintaining a high degree of reliability and safety.http://dx.doi.org/10.1080/21645515.2017.1345833engineered adoptive cell therapypathogen-boosted vaccination |
| spellingShingle | Ryan Zander Weiguo Cui The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors Human Vaccines & Immunotherapeutics engineered adoptive cell therapy pathogen-boosted vaccination |
| title | The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors |
| title_full | The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors |
| title_fullStr | The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors |
| title_full_unstemmed | The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors |
| title_short | The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors |
| title_sort | power of combining adoptive cell therapy act and pathogen boosted vaccination to treat solid tumors |
| topic | engineered adoptive cell therapy pathogen-boosted vaccination |
| url | http://dx.doi.org/10.1080/21645515.2017.1345833 |
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