Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback
Adolescent depression is prevalent, debilitating, and associated with chronic lifetime mental health disorders. Understanding the neurobiology of depression is critical to developing novel treatments. We tested a neurofeedback protocol targeting emotional regulation and self-processing circuitry and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/9/1128 |
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| author | Natasha Ahrweiler Carmen Santana-Gonzalez Na Zhang Grace Quandt Nikki Ashtiani Guanmin Liu Maggie Engstrom Erika Schultz Ryan Liengswangwong Jia Yuan Teoh Katia Kozachok Karina Quevedo |
| author_facet | Natasha Ahrweiler Carmen Santana-Gonzalez Na Zhang Grace Quandt Nikki Ashtiani Guanmin Liu Maggie Engstrom Erika Schultz Ryan Liengswangwong Jia Yuan Teoh Katia Kozachok Karina Quevedo |
| author_sort | Natasha Ahrweiler |
| collection | DOAJ |
| description | Adolescent depression is prevalent, debilitating, and associated with chronic lifetime mental health disorders. Understanding the neurobiology of depression is critical to developing novel treatments. We tested a neurofeedback protocol targeting emotional regulation and self-processing circuitry and examined brain activity associated with reduced symptom severity, as measured through self-report questionnaires, four hours after neurofeedback. Depressed (<i>n</i> = 34) and healthy (<i>n</i> = 19) adolescents participated in (i) a brief neurofeedback task that involves simultaneously viewing their own happy face, recalling a positive autobiographical memory, and increasing amygdala-hippocampal activity; (ii) a self- vs. other- face recognition task with happy, neutral, and sad facial expressions before and after the neurofeedback. In depressed youth, reduced depression after neurofeedback was associated with increased self-referential and visual areas’ activity during neurofeedback, specifically, increased activity in the cuneus, precuneus and parietal lobe. Reduced depression was also associated with increased activation of emotional regulation and cross-modal areas during a self-recognition task. These areas included the cerebellum, middle temporal gyrus, superior temporal gyrus, and supramarginal gyrus. However, decreased rumination was linked to decreased precuneus, angular and temporal gyri activity during neurofeedback. These results tentatively suggest that neurofeedback may induce short-term neurobiological changes in the self-referential and emotional regulation networks associated with reduced symptom severity among depressed adolescents. |
| first_indexed | 2024-03-10T00:34:50Z |
| format | Article |
| id | doaj.art-dbad0d8ab06d485c826261510aacb205 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T00:34:50Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-dbad0d8ab06d485c826261510aacb2052023-11-23T15:19:39ZengMDPI AGBrain Sciences2076-34252022-08-01129112810.3390/brainsci12091128Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing NeurofeedbackNatasha Ahrweiler0Carmen Santana-Gonzalez1Na Zhang2Grace Quandt3Nikki Ashtiani4Guanmin Liu5Maggie Engstrom6Erika Schultz7Ryan Liengswangwong8Jia Yuan Teoh9Katia Kozachok10Karina Quevedo11Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Human Development and Family Sciences, University of Connecticut, Storrs, CT 06269, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USADepartment of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USAAdolescent depression is prevalent, debilitating, and associated with chronic lifetime mental health disorders. Understanding the neurobiology of depression is critical to developing novel treatments. We tested a neurofeedback protocol targeting emotional regulation and self-processing circuitry and examined brain activity associated with reduced symptom severity, as measured through self-report questionnaires, four hours after neurofeedback. Depressed (<i>n</i> = 34) and healthy (<i>n</i> = 19) adolescents participated in (i) a brief neurofeedback task that involves simultaneously viewing their own happy face, recalling a positive autobiographical memory, and increasing amygdala-hippocampal activity; (ii) a self- vs. other- face recognition task with happy, neutral, and sad facial expressions before and after the neurofeedback. In depressed youth, reduced depression after neurofeedback was associated with increased self-referential and visual areas’ activity during neurofeedback, specifically, increased activity in the cuneus, precuneus and parietal lobe. Reduced depression was also associated with increased activation of emotional regulation and cross-modal areas during a self-recognition task. These areas included the cerebellum, middle temporal gyrus, superior temporal gyrus, and supramarginal gyrus. However, decreased rumination was linked to decreased precuneus, angular and temporal gyri activity during neurofeedback. These results tentatively suggest that neurofeedback may induce short-term neurobiological changes in the self-referential and emotional regulation networks associated with reduced symptom severity among depressed adolescents.https://www.mdpi.com/2076-3425/12/9/1128depressionneurofeedbackadolescentsself-processing networkneuroplasticityself-processing |
| spellingShingle | Natasha Ahrweiler Carmen Santana-Gonzalez Na Zhang Grace Quandt Nikki Ashtiani Guanmin Liu Maggie Engstrom Erika Schultz Ryan Liengswangwong Jia Yuan Teoh Katia Kozachok Karina Quevedo Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback Brain Sciences depression neurofeedback adolescents self-processing network neuroplasticity self-processing |
| title | Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback |
| title_full | Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback |
| title_fullStr | Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback |
| title_full_unstemmed | Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback |
| title_short | Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback |
| title_sort | neural activity associated with symptoms change in depressed adolescents following self processing neurofeedback |
| topic | depression neurofeedback adolescents self-processing network neuroplasticity self-processing |
| url | https://www.mdpi.com/2076-3425/12/9/1128 |
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