The hypothetical ancestral animal. the Urmetazoa: telomerase activity in sponges (Porifera)
Sponges (Porifera) represent the lowest metazoan phylum, characterized by a pronounced plasticity in the determination of cell lineages, and they are the closest related taxon to the hypothetical ancestral animal, the Urmetazoa, from which the metazoan lineages diverged. In a first approach to eluci...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2003-05-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.yu/HtDocs/SHD/Vol68/No4-5/V68-No4_5-03.pdf |
| _version_ | 1818757590760292352 |
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| author | ISABEL M. MÜLLER WERNER E. G. MÜLLER |
| author_facet | ISABEL M. MÜLLER WERNER E. G. MÜLLER |
| author_sort | ISABEL M. MÜLLER |
| collection | DOAJ |
| description | Sponges (Porifera) represent the lowest metazoan phylum, characterized by a pronounced plasticity in the determination of cell lineages, and they are the closest related taxon to the hypothetical ancestral animal, the Urmetazoa, from which the metazoan lineages diverged. In a first approach to elucidate the molecular mechanisms controlling the switch from the cell lineage with a putative indefinite growth capacity to senescent, somatic cells, the activity of the telomerase as an indicator for immortality has been determined. The studies were performed with the marine demosponges Suberites domuncula and Geodia cydonium, in vivo with tissue but also in vitro using the primmorph system. Primmorphs are formed from dissociated cells which have retained their proliferation potency. It was found that the activity of telomerase in tissue of both sponges is high. Based on this and additional findings it is assumed that the separation of the senescent sponge cell lineage from the immortal germ-/somatic cell lineage is triggered by the loss of contact to cell adhesion factors. First evidence is included which suggests that the final progress of the senescent, telomerase-negative cells to cell death is caused by apoptosis. |
| first_indexed | 2024-12-18T06:13:22Z |
| format | Article |
| id | doaj.art-dbadc4c330f147448b266222d5da7d38 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-18T06:13:22Z |
| publishDate | 2003-05-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-dbadc4c330f147448b266222d5da7d382022-12-21T21:18:20ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392003-05-01684-5257268The hypothetical ancestral animal. the Urmetazoa: telomerase activity in sponges (Porifera)ISABEL M. MÜLLERWERNER E. G. MÜLLERSponges (Porifera) represent the lowest metazoan phylum, characterized by a pronounced plasticity in the determination of cell lineages, and they are the closest related taxon to the hypothetical ancestral animal, the Urmetazoa, from which the metazoan lineages diverged. In a first approach to elucidate the molecular mechanisms controlling the switch from the cell lineage with a putative indefinite growth capacity to senescent, somatic cells, the activity of the telomerase as an indicator for immortality has been determined. The studies were performed with the marine demosponges Suberites domuncula and Geodia cydonium, in vivo with tissue but also in vitro using the primmorph system. Primmorphs are formed from dissociated cells which have retained their proliferation potency. It was found that the activity of telomerase in tissue of both sponges is high. Based on this and additional findings it is assumed that the separation of the senescent sponge cell lineage from the immortal germ-/somatic cell lineage is triggered by the loss of contact to cell adhesion factors. First evidence is included which suggests that the final progress of the senescent, telomerase-negative cells to cell death is caused by apoptosis.http://www.shd.org.yu/HtDocs/SHD/Vol68/No4-5/V68-No4_5-03.pdfSuberites domunculaGeodia cydoniumprimmorphssenescencetelomerestelomerasecell lineagesUrmetazoa |
| spellingShingle | ISABEL M. MÜLLER WERNER E. G. MÜLLER The hypothetical ancestral animal. the Urmetazoa: telomerase activity in sponges (Porifera) Journal of the Serbian Chemical Society Suberites domuncula Geodia cydonium primmorphs senescence telomeres telomerase cell lineages Urmetazoa |
| title | The hypothetical ancestral animal. the Urmetazoa: telomerase activity in sponges (Porifera) |
| title_full | The hypothetical ancestral animal. the Urmetazoa: telomerase activity in sponges (Porifera) |
| title_fullStr | The hypothetical ancestral animal. the Urmetazoa: telomerase activity in sponges (Porifera) |
| title_full_unstemmed | The hypothetical ancestral animal. the Urmetazoa: telomerase activity in sponges (Porifera) |
| title_short | The hypothetical ancestral animal. the Urmetazoa: telomerase activity in sponges (Porifera) |
| title_sort | hypothetical ancestral animal the urmetazoa telomerase activity in sponges porifera |
| topic | Suberites domuncula Geodia cydonium primmorphs senescence telomeres telomerase cell lineages Urmetazoa |
| url | http://www.shd.org.yu/HtDocs/SHD/Vol68/No4-5/V68-No4_5-03.pdf |
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