Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database
Objectives We aimed to investigate the association between red cell distribution width-to-platelet ratio (RPR), and in-hospital mortality in critically ill patients with acute myocardial infarction (AMI).Design A retrospective cohort study.Setting Data were collected from the Medical Information Mar...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/9/e062384.full |
| _version_ | 1811211868524511232 |
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| author | Quan Zhou Li Tong Yan-Qiong Liu Jin Hua Shen Min B O Xiang-Jie Duan Ya Fen Guo Xue Qing Zhang |
| author_facet | Quan Zhou Li Tong Yan-Qiong Liu Jin Hua Shen Min B O Xiang-Jie Duan Ya Fen Guo Xue Qing Zhang |
| author_sort | Quan Zhou |
| collection | DOAJ |
| description | Objectives We aimed to investigate the association between red cell distribution width-to-platelet ratio (RPR), and in-hospital mortality in critically ill patients with acute myocardial infarction (AMI).Design A retrospective cohort study.Setting Data were collected from the Medical Information Mart for Intensive Care database (MIMIC-IV) consisting of critically ill participants between 2008 and 2019 at the Beth Israel Deaconess Medical Centre in Boston.Participants A total of 5067 patients with AMI were enrolled from the MIMIC-IV database.Primary and secondary outcome In-hospital mortality.Results A total of 4034 patients survived, while 1033 died. In a multiple regression analysis adjusted for age, weight and ethnicity, RPR also showed a positive correlation with in-hospital mortality (HR 1.91, 95% CI 1.42 to 2.56, p<0.0001). Moreover, after adjusting for additional confounding factors, obvious changes were observed (HR 1.63, 95% CI 1.03 to 2.57, p=0.0357). In model 2, the high ratio quartile remained positively associated with hospital mortality compared with the low ratio quartile (HR 1.20, 95% CI 1.01 to 1. 43), with a p-value trend of 0.0177. Subgroup analyses showed no significant effect modifications on the association between RPR and in-hospital mortality in the different AMI groups (p>0.05).Conclusion RPR is an independent predictor of in-hospital mortality in critically ill patients with AMI. |
| first_indexed | 2024-04-12T05:20:37Z |
| format | Article |
| id | doaj.art-dbadfc1a94f64fa99d45bbf7824d9f6a |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-12T05:20:37Z |
| publishDate | 2022-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-dbadfc1a94f64fa99d45bbf7824d9f6a2022-12-22T03:46:29ZengBMJ Publishing GroupBMJ Open2044-60552022-09-0112910.1136/bmjopen-2022-062384Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV databaseQuan Zhou0Li Tong1Yan-Qiong Liu2Jin Hua Shen3Min B O4Xiang-Jie Duan5Ya Fen Guo6Xue Qing Zhang7Department of Science and Education, First People`s Hospital of Changde City, Changde, Hunan, ChinaDepartment of Nursing, First People`s Hospital of Changde City, Changde, Hunan, ChinaDepartment of Nursing, First People`s Hospital of Changde City, Changde, Hunan, ChinaDepartment of Nursing, First People`s Hospital of Changde City, Changde, Hunan, ChinaDepartment of Nursing, First People`s Hospital of Changde City, Changde, Hunan, ChinaDepartment of Infectious Diseases, First People`s Hospital of Changde City, Changde, Hunan, ChinaDepartment of Nursing, First People`s Hospital of Changde City, Changde, Hunan, ChinaDepartment of Nursing, First People`s Hospital of Changde City, Changde, Hunan, ChinaObjectives We aimed to investigate the association between red cell distribution width-to-platelet ratio (RPR), and in-hospital mortality in critically ill patients with acute myocardial infarction (AMI).Design A retrospective cohort study.Setting Data were collected from the Medical Information Mart for Intensive Care database (MIMIC-IV) consisting of critically ill participants between 2008 and 2019 at the Beth Israel Deaconess Medical Centre in Boston.Participants A total of 5067 patients with AMI were enrolled from the MIMIC-IV database.Primary and secondary outcome In-hospital mortality.Results A total of 4034 patients survived, while 1033 died. In a multiple regression analysis adjusted for age, weight and ethnicity, RPR also showed a positive correlation with in-hospital mortality (HR 1.91, 95% CI 1.42 to 2.56, p<0.0001). Moreover, after adjusting for additional confounding factors, obvious changes were observed (HR 1.63, 95% CI 1.03 to 2.57, p=0.0357). In model 2, the high ratio quartile remained positively associated with hospital mortality compared with the low ratio quartile (HR 1.20, 95% CI 1.01 to 1. 43), with a p-value trend of 0.0177. Subgroup analyses showed no significant effect modifications on the association between RPR and in-hospital mortality in the different AMI groups (p>0.05).Conclusion RPR is an independent predictor of in-hospital mortality in critically ill patients with AMI.https://bmjopen.bmj.com/content/12/9/e062384.full |
| spellingShingle | Quan Zhou Li Tong Yan-Qiong Liu Jin Hua Shen Min B O Xiang-Jie Duan Ya Fen Guo Xue Qing Zhang Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database BMJ Open |
| title | Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database |
| title_full | Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database |
| title_fullStr | Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database |
| title_full_unstemmed | Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database |
| title_short | Relationship between the red cell distribution width-to-platelet ratio and in-hospital mortality among critically ill patients with acute myocardial infarction: a retrospective analysis of the MIMIC-IV database |
| title_sort | relationship between the red cell distribution width to platelet ratio and in hospital mortality among critically ill patients with acute myocardial infarction a retrospective analysis of the mimic iv database |
| url | https://bmjopen.bmj.com/content/12/9/e062384.full |
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