Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea®)
Antrodia cinnamomea is a rare and endemic medicinal mushroom native to Taiwan. The pharmacological effects of A. cinnamomea have been extensively studied. The aim of the present study was to assess the genotoxic, oral toxic and teratotoxic effects of A. cinnamomea health food product “Leader Deluxe...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221475001530072X |
| _version_ | 1818418260682473472 |
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| author | Chin-Chung Lin K.J. Senthil Kumar Jiunn-Wang Liao Yueh-Hsiung Kuo Sheng-Yang Wang |
| author_facet | Chin-Chung Lin K.J. Senthil Kumar Jiunn-Wang Liao Yueh-Hsiung Kuo Sheng-Yang Wang |
| author_sort | Chin-Chung Lin |
| collection | DOAJ |
| description | Antrodia cinnamomea is a rare and endemic medicinal mushroom native to Taiwan. The pharmacological effects of A. cinnamomea have been extensively studied. The aim of the present study was to assess the genotoxic, oral toxic and teratotoxic effects of A. cinnamomea health food product “Leader Deluxe Antrodia cinnamomea (LDAC)’’ using in vitro and in vivo tests. The Ames test with 5 strains of Salmonella typhimurium showed no signs of increased reverse mutation upon exposure to LDAC up to concentration of 5 mg/plate. Exposure of Chinese Hamster Ovary cells (CHO-K1) to LDAC did not produce an increase in the frequency of chromosomal aberration in vitro. In addition, LDAC treatment did not affect the proportions of immature to total erythrocytes and the number of micronuclei in the immature erythrocytes of ICR mice. Moreover, 14-days single-dose acute toxicity and 90-days repeated oral dose toxicity tests with rats showed that no observable adverse effects were found. Furthermore, after treatment with LDAC (700–2800 mg/kg/day) there was no evidence of observable segment II reproductive and developmental toxic effects in pregnant SD rats and their fetuses. These toxicological assessments support the safety of LDAC for human consumption. |
| first_indexed | 2024-12-14T12:19:51Z |
| format | Article |
| id | doaj.art-dbae87e040324992a79219936c4e4371 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-14T12:19:51Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-dbae87e040324992a79219936c4e43712022-12-21T23:01:32ZengElsevierToxicology Reports2214-75002015-01-012C1409141710.1016/j.toxrep.2015.10.007Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea®)Chin-Chung Lin0K.J. Senthil Kumar1Jiunn-Wang Liao2Yueh-Hsiung Kuo3Sheng-Yang Wang4Taiwan Leader Biotech Company, Taipei, TaiwanDepartment of Forestry, National Chung Hsing University, Taichung, TaiwanGraduate Institute of Veterinary Pathology, National Chung Hsing University, Taichung, TaiwanGraduate Institute of Chinese Pharmaceutical Science, China Medical University, Taichung, TaiwanDepartment of Forestry, National Chung Hsing University, Taichung, TaiwanAntrodia cinnamomea is a rare and endemic medicinal mushroom native to Taiwan. The pharmacological effects of A. cinnamomea have been extensively studied. The aim of the present study was to assess the genotoxic, oral toxic and teratotoxic effects of A. cinnamomea health food product “Leader Deluxe Antrodia cinnamomea (LDAC)’’ using in vitro and in vivo tests. The Ames test with 5 strains of Salmonella typhimurium showed no signs of increased reverse mutation upon exposure to LDAC up to concentration of 5 mg/plate. Exposure of Chinese Hamster Ovary cells (CHO-K1) to LDAC did not produce an increase in the frequency of chromosomal aberration in vitro. In addition, LDAC treatment did not affect the proportions of immature to total erythrocytes and the number of micronuclei in the immature erythrocytes of ICR mice. Moreover, 14-days single-dose acute toxicity and 90-days repeated oral dose toxicity tests with rats showed that no observable adverse effects were found. Furthermore, after treatment with LDAC (700–2800 mg/kg/day) there was no evidence of observable segment II reproductive and developmental toxic effects in pregnant SD rats and their fetuses. These toxicological assessments support the safety of LDAC for human consumption.http://www.sciencedirect.com/science/article/pii/S221475001530072XAntrodia cinnamomeaLeader Deluxe Antrodia cinnamomeaGenotoxicityMutagenicityChromosomal aberrationMicronuclei |
| spellingShingle | Chin-Chung Lin K.J. Senthil Kumar Jiunn-Wang Liao Yueh-Hsiung Kuo Sheng-Yang Wang Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea®) Toxicology Reports Antrodia cinnamomea Leader Deluxe Antrodia cinnamomea Genotoxicity Mutagenicity Chromosomal aberration Micronuclei |
| title | Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea®) |
| title_full | Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea®) |
| title_fullStr | Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea®) |
| title_full_unstemmed | Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea®) |
| title_short | Genotoxic, teratotoxic and oral toxic assessments of Antrodia cinnamomea health food product (Leader Deluxe Antrodia cinnamomea®) |
| title_sort | genotoxic teratotoxic and oral toxic assessments of antrodia cinnamomea health food product leader deluxe antrodia cinnamomea r |
| topic | Antrodia cinnamomea Leader Deluxe Antrodia cinnamomea Genotoxicity Mutagenicity Chromosomal aberration Micronuclei |
| url | http://www.sciencedirect.com/science/article/pii/S221475001530072X |
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