Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique
Abstract Background Healthcare workers in high tuberculosis burdened countries are occupationally exposed to the tuberculosis disease with uncomplicated and complicated tuberculosis on the increase among them. Most of them acquire Mycobacterium tuberculosis but do not progress to the active disease...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2516-4 |
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| author | Celso Belo Saloshni Naidoo |
| author_facet | Celso Belo Saloshni Naidoo |
| author_sort | Celso Belo |
| collection | DOAJ |
| description | Abstract Background Healthcare workers in high tuberculosis burdened countries are occupationally exposed to the tuberculosis disease with uncomplicated and complicated tuberculosis on the increase among them. Most of them acquire Mycobacterium tuberculosis but do not progress to the active disease – latent tuberculosis infection. The objective of this study was to assess the prevalence and risk factors associated with latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique. Methods This cross-sectional study of healthcare workers was conducted between 2014 and 2015. Participants (n = 209) were administered a questionnaire on demographics and occupational tuberculosis exposure and had a tuberculin skin test administered. Multivariate linear and logistic regression tested for associations between independent variables and dependent outcomes (tuberculin skin test induration and latent tuberculosis infection status). Results The prevalence of latent tuberculosis infection was 34.4%. Latent tuberculosis infection was highest in those working for more than eight years (39.3%), those who had no BCG vaccination (39.6%) and were immunocompromised (78.1%). Being immunocompromised was significantly associated with latent tuberculosis infection (OR 5.97 [95% CI 1.89; 18.87]). Positive but non-significant associations occurred with working in the medical domain (OR 1.02 [95% CI 0.17; 6.37]), length of employment > eight years (OR 1.97 [95% CI 0.70; 5.53]) and occupational contact with tuberculosis patients (OR 1.24 [95% CI 0.47; 3.27]). Conclusions Personal and occupational factors were positively associated with latent tuberculosis infection among healthcare workers in Mozambique. |
| first_indexed | 2024-12-13T02:39:48Z |
| format | Article |
| id | doaj.art-dbaf2dc2badd4862ab0eecc7d13c843e |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T02:39:48Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-dbaf2dc2badd4862ab0eecc7d13c843e2022-12-22T00:02:19ZengBMCBMC Infectious Diseases1471-23342017-06-0117111010.1186/s12879-017-2516-4Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, MozambiqueCelso Belo0Saloshni Naidoo1Department of Medicine, Faculty of Health Sciences, Lúrio UniversityDiscipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-NatalAbstract Background Healthcare workers in high tuberculosis burdened countries are occupationally exposed to the tuberculosis disease with uncomplicated and complicated tuberculosis on the increase among them. Most of them acquire Mycobacterium tuberculosis but do not progress to the active disease – latent tuberculosis infection. The objective of this study was to assess the prevalence and risk factors associated with latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique. Methods This cross-sectional study of healthcare workers was conducted between 2014 and 2015. Participants (n = 209) were administered a questionnaire on demographics and occupational tuberculosis exposure and had a tuberculin skin test administered. Multivariate linear and logistic regression tested for associations between independent variables and dependent outcomes (tuberculin skin test induration and latent tuberculosis infection status). Results The prevalence of latent tuberculosis infection was 34.4%. Latent tuberculosis infection was highest in those working for more than eight years (39.3%), those who had no BCG vaccination (39.6%) and were immunocompromised (78.1%). Being immunocompromised was significantly associated with latent tuberculosis infection (OR 5.97 [95% CI 1.89; 18.87]). Positive but non-significant associations occurred with working in the medical domain (OR 1.02 [95% CI 0.17; 6.37]), length of employment > eight years (OR 1.97 [95% CI 0.70; 5.53]) and occupational contact with tuberculosis patients (OR 1.24 [95% CI 0.47; 3.27]). Conclusions Personal and occupational factors were positively associated with latent tuberculosis infection among healthcare workers in Mozambique.http://link.springer.com/article/10.1186/s12879-017-2516-4Tuberculin skin testImmunosuppressionAdministrative control measures |
| spellingShingle | Celso Belo Saloshni Naidoo Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique BMC Infectious Diseases Tuberculin skin test Immunosuppression Administrative control measures |
| title | Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique |
| title_full | Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique |
| title_fullStr | Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique |
| title_full_unstemmed | Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique |
| title_short | Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Nampula Central Hospital, Mozambique |
| title_sort | prevalence and risk factors for latent tuberculosis infection among healthcare workers in nampula central hospital mozambique |
| topic | Tuberculin skin test Immunosuppression Administrative control measures |
| url | http://link.springer.com/article/10.1186/s12879-017-2516-4 |
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