Reducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous Leukemia
Summary: Donor site preparation is a critical step before the application of an autologous split-thickness skin graft (STSG). Comorbidities can lead to complications and graft loss, including that due to hematoma. In this case, a bilayer collagen matrix was used as a temporary wound dressing in a 25...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2019-11-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002532 |
| _version_ | 1818300339667861504 |
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| author | Alexis L. Lo, BS Richard O. Tyrell, MD Scott R. Golarz, MD Christine M. Jones, MD |
| author_facet | Alexis L. Lo, BS Richard O. Tyrell, MD Scott R. Golarz, MD Christine M. Jones, MD |
| author_sort | Alexis L. Lo, BS |
| collection | DOAJ |
| description | Summary: Donor site preparation is a critical step before the application of an autologous split-thickness skin graft (STSG). Comorbidities can lead to complications and graft loss, including that due to hematoma. In this case, a bilayer collagen matrix was used as a temporary wound dressing in a 25-year-old woman with active chronic myelogenous leukemia. She presented with a bleeding diathesis and spontaneous intramuscular and intracompartmental hematomas of the right leg. She experienced ongoing high-volume blood loss from her fasciotomy wounds, requiring wound care to be performed in the operating room under general anesthesia, and requiring multiple blood and platelet transfusions. Instead of immediate STSG, a bilayer collagen matrix was placed to reduce the bleeding and further prepare the wound bed over a 9-week period while she underwent medical optimization. Once stabilized from a hematologic standpoint, STSG was performed with total graft take. Both uncontrolled chronic myelogenous leukemia and its therapy, tyrosine kinase inhibitors, have a risk of hemorrhagic and thrombotic complications. Bilayer collagen matrix serves as an adjunct in the limb salvage algorithm that can reduce transfusion needs whereas a temporary bleeding diathesis is medically corrected before the application of an autologous skin graft. |
| first_indexed | 2024-12-13T05:05:33Z |
| format | Article |
| id | doaj.art-dbb4b9942b0d40e1baee284064e77029 |
| institution | Directory Open Access Journal |
| issn | 2169-7574 |
| language | English |
| last_indexed | 2024-12-13T05:05:33Z |
| publishDate | 2019-11-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj.art-dbb4b9942b0d40e1baee284064e770292022-12-21T23:58:41ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742019-11-01711e253210.1097/GOX.0000000000002532201911000-00040Reducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous LeukemiaAlexis L. Lo, BS0Richard O. Tyrell, MD1Scott R. Golarz, MD2Christine M. Jones, MD3From the *Division of Plastic and Reconstructive Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pa.From the *Division of Plastic and Reconstructive Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pa.†Division of Vascular Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pa.From the *Division of Plastic and Reconstructive Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pa.Summary: Donor site preparation is a critical step before the application of an autologous split-thickness skin graft (STSG). Comorbidities can lead to complications and graft loss, including that due to hematoma. In this case, a bilayer collagen matrix was used as a temporary wound dressing in a 25-year-old woman with active chronic myelogenous leukemia. She presented with a bleeding diathesis and spontaneous intramuscular and intracompartmental hematomas of the right leg. She experienced ongoing high-volume blood loss from her fasciotomy wounds, requiring wound care to be performed in the operating room under general anesthesia, and requiring multiple blood and platelet transfusions. Instead of immediate STSG, a bilayer collagen matrix was placed to reduce the bleeding and further prepare the wound bed over a 9-week period while she underwent medical optimization. Once stabilized from a hematologic standpoint, STSG was performed with total graft take. Both uncontrolled chronic myelogenous leukemia and its therapy, tyrosine kinase inhibitors, have a risk of hemorrhagic and thrombotic complications. Bilayer collagen matrix serves as an adjunct in the limb salvage algorithm that can reduce transfusion needs whereas a temporary bleeding diathesis is medically corrected before the application of an autologous skin graft.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002532 |
| spellingShingle | Alexis L. Lo, BS Richard O. Tyrell, MD Scott R. Golarz, MD Christine M. Jones, MD Reducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous Leukemia Plastic and Reconstructive Surgery, Global Open |
| title | Reducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous Leukemia |
| title_full | Reducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous Leukemia |
| title_fullStr | Reducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous Leukemia |
| title_full_unstemmed | Reducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous Leukemia |
| title_short | Reducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous Leukemia |
| title_sort | reducing wound hemorrhage use of bilayer collagen matrix in chronic myelogenous leukemia |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000002532 |
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