Stimuli-responsive nano vehicle enhances cancer immunotherapy by coordinating mitochondria-targeted immunogenic cell death and PD-L1 blockade

Stimuli-responsive nano vehicle enhances cancer immunotherapy by coordinating mitochondria-targeted immunogenic cell death and PD-L1 blockade

Induction of immunogenic cell death promotes antitumor immunity against cancer. However, majority of clinically-approved drugs are unable to elicit sufficient ICD. Here, our study revealed that mitochondria-targeted delivery of doxorubicin (DOX) massively amplified ICD via substantial generation of...

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Bibliographic Details
Main Authors:	Qiuyi Li, Cheng Chen, Jinxia Kong, Lian Li, Junlin Li, Yuan Huang
Format:	Article
Language:	English
Published:	Elsevier 2022-05-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Immunogenic cell death Mitochondrial targeting PD-L1 blockade Endoplasmic reticulum stress Mitochondria-associated damage molecules Stimuli-responsive
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383521004378

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