Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: A retrospective study based on MIMIC-Ⅲ and Ⅳ databases.
<h4>Background</h4>To investigate the correlation between albumin-corrected anion gap(ACAG) within the first 24 hours of admission and in-hospital mortality in trauma patients in intensive care unit(ICU).<h4>Materials and methods</h4>We utilized the MIMIC-Ⅲ and MIMIC-Ⅳ databa...
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Public Library of Science (PLoS)
2024-01-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300012&type=printable |
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| author | Fei Yin Zhenguo Qiao Xiaofei Wu Qiang Shi Rongfei Jin Yuzhou Xu |
| author_facet | Fei Yin Zhenguo Qiao Xiaofei Wu Qiang Shi Rongfei Jin Yuzhou Xu |
| author_sort | Fei Yin |
| collection | DOAJ |
| description | <h4>Background</h4>To investigate the correlation between albumin-corrected anion gap(ACAG) within the first 24 hours of admission and in-hospital mortality in trauma patients in intensive care unit(ICU).<h4>Materials and methods</h4>We utilized the MIMIC-Ⅲ and MIMIC-Ⅳ databases to examine trauma patients admitted to the ICU. The relationship between ACAG and in-hospital mortality in trauma patients was analyzed using Receiver Operating Characteristic(ROC) curve, Kaplan-Meier (K-M) survival curve, and Cox regression model. Propensity score matching (PSM) and subgroup analysis were conducted to enhance stability and reliability of the findings. Mortality at 30-day and 90-day served as secondary outcomes.<h4>Results</h4>The study enrolled a total of 1038 patients. The AUC for ACAG (0.701, 95%CI: 0.652-0.749) was notably higher than that for anion gap and albumin. The Log-rank test revealed that the optimal cut-off point of ACAG for predicting in-hospital mortality was determined to be 20.375mmol/L. The multivariate Cox regression analysis demonstrated an independent association between high ACAG level and a higher risk of in-hospital mortality (HR = 3.128, 95% CI: 1.615-6.059). After PSM analysis, a matched cohort consisting of 291 subjects was obtained. We found no signifcant interaction in most stratas. Finally, The in-hospital, 30-day, and 90-day survival rates in the high ACAG group exhibited a statistically decrease compared to those in the low ACAG group both pre- and post-matching.<h4>Conclusion</h4>The elevated level of ACAG was found to be independently associated with increased in-hospital mortality among trauma patients in the ICU. |
| first_indexed | 2024-04-25T00:14:59Z |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-25T00:14:59Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dbb5a2c7744e403e9b530bfa9acc49eb2024-03-13T05:31:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01193e030001210.1371/journal.pone.0300012Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: A retrospective study based on MIMIC-Ⅲ and Ⅳ databases.Fei YinZhenguo QiaoXiaofei WuQiang ShiRongfei JinYuzhou Xu<h4>Background</h4>To investigate the correlation between albumin-corrected anion gap(ACAG) within the first 24 hours of admission and in-hospital mortality in trauma patients in intensive care unit(ICU).<h4>Materials and methods</h4>We utilized the MIMIC-Ⅲ and MIMIC-Ⅳ databases to examine trauma patients admitted to the ICU. The relationship between ACAG and in-hospital mortality in trauma patients was analyzed using Receiver Operating Characteristic(ROC) curve, Kaplan-Meier (K-M) survival curve, and Cox regression model. Propensity score matching (PSM) and subgroup analysis were conducted to enhance stability and reliability of the findings. Mortality at 30-day and 90-day served as secondary outcomes.<h4>Results</h4>The study enrolled a total of 1038 patients. The AUC for ACAG (0.701, 95%CI: 0.652-0.749) was notably higher than that for anion gap and albumin. The Log-rank test revealed that the optimal cut-off point of ACAG for predicting in-hospital mortality was determined to be 20.375mmol/L. The multivariate Cox regression analysis demonstrated an independent association between high ACAG level and a higher risk of in-hospital mortality (HR = 3.128, 95% CI: 1.615-6.059). After PSM analysis, a matched cohort consisting of 291 subjects was obtained. We found no signifcant interaction in most stratas. Finally, The in-hospital, 30-day, and 90-day survival rates in the high ACAG group exhibited a statistically decrease compared to those in the low ACAG group both pre- and post-matching.<h4>Conclusion</h4>The elevated level of ACAG was found to be independently associated with increased in-hospital mortality among trauma patients in the ICU.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300012&type=printable |
| spellingShingle | Fei Yin Zhenguo Qiao Xiaofei Wu Qiang Shi Rongfei Jin Yuzhou Xu Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: A retrospective study based on MIMIC-Ⅲ and Ⅳ databases. PLoS ONE |
| title | Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: A retrospective study based on MIMIC-Ⅲ and Ⅳ databases. |
| title_full | Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: A retrospective study based on MIMIC-Ⅲ and Ⅳ databases. |
| title_fullStr | Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: A retrospective study based on MIMIC-Ⅲ and Ⅳ databases. |
| title_full_unstemmed | Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: A retrospective study based on MIMIC-Ⅲ and Ⅳ databases. |
| title_short | Association between albumin-corrected anion gap and in-hospital mortality of intensive care patients with trauma: A retrospective study based on MIMIC-Ⅲ and Ⅳ databases. |
| title_sort | association between albumin corrected anion gap and in hospital mortality of intensive care patients with trauma a retrospective study based on mimic iii and iv databases |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300012&type=printable |
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