Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats
Introduction Extravasation injuries are one of the most feared complications of intravenous drug administration. The most common drugs associated with extravasation injury include chemotherapy agents and contrast media. Natural course of vesicant extravasation is discomfort, pain, swelling, inflamma...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-04-01
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| Series: | Journal of Investigative Surgery |
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| Online Access: | http://dx.doi.org/10.1080/08941939.2021.1966142 |
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| author | Ahmet Bicer Burak Sercan Ercin Tahir Gürler Gürkan Yiğittürk Yigit Uyanikgil Emel Oyku Cetin |
| author_facet | Ahmet Bicer Burak Sercan Ercin Tahir Gürler Gürkan Yiğittürk Yigit Uyanikgil Emel Oyku Cetin |
| author_sort | Ahmet Bicer |
| collection | DOAJ |
| description | Introduction Extravasation injuries are one of the most feared complications of intravenous drug administration. The most common drugs associated with extravasation injury include chemotherapy agents and contrast media. Natural course of vesicant extravasation is discomfort, pain, swelling, inflammation, and ultimately skin ulceration. While diligence is the principle approach in prevention, immediate bed-side measures are as important in controlling the extent of tissue damage. Various options, either medical or interventional are next steps in treatment of the condition including antidotes, volume dilution, flushing, suction, hyperbaric oxygen therapy, and surgery. Materials and methods 12 male Wistar albino rats were divided into two groups; one group received fat injections following subdermal doxorubicin infiltration in their right thighs, while other group received saline injection following subdermal doxorubicin infiltration in their right thighs for dilution. Left thighs of both groups were left untreated following subdermal doxorubicin infiltration. Total area of necrosis, as well as resultant epidermal thicknesses were assessed. Histological analyses were conducted using modified Verhofstad scoring system for comparison. Results Mean necrotic area was significantly smaller in the fat injection group compared to other groups. Median Verhofstad score was lesser in the fat injection group as well. Median epidermal thickness, on the other hand, was greater in the fat injection group. Conclusion Injection of fat grafts following vesicant extravasation might be beneficial in preventing the progression of tissue damage, if employed early. |
| first_indexed | 2024-03-12T00:30:36Z |
| format | Article |
| id | doaj.art-dbb5ae90810a471fa4ed673be5437dd0 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:30:36Z |
| publishDate | 2022-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-dbb5ae90810a471fa4ed673be5437dd02023-09-15T10:21:28ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532022-04-0135480180810.1080/08941939.2021.19661421966142Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in RatsAhmet Bicer0Burak Sercan Ercin1Tahir Gürler2Gürkan Yiğittürk3Yigit Uyanikgil4Emel Oyku Cetin5Department of Plastic Surgery, Faculty of Medicine, Ege UniversityDepartment of Plastic, Reconstructive and Aesthetic surgery, Bahcesehir UniversityDepartment of Plastic Surgery, Faculty of Medicine, Ege UniversityDepartment of Histology and Embryology, Faculty of Medicine, Mugla Sitki Kocman UniversityDepartment of Histology and Embryology, Faculty of Medicine, Ege UniversityDepartment of Pharmaceutical Technology, Department of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, Ege UniversityIntroduction Extravasation injuries are one of the most feared complications of intravenous drug administration. The most common drugs associated with extravasation injury include chemotherapy agents and contrast media. Natural course of vesicant extravasation is discomfort, pain, swelling, inflammation, and ultimately skin ulceration. While diligence is the principle approach in prevention, immediate bed-side measures are as important in controlling the extent of tissue damage. Various options, either medical or interventional are next steps in treatment of the condition including antidotes, volume dilution, flushing, suction, hyperbaric oxygen therapy, and surgery. Materials and methods 12 male Wistar albino rats were divided into two groups; one group received fat injections following subdermal doxorubicin infiltration in their right thighs, while other group received saline injection following subdermal doxorubicin infiltration in their right thighs for dilution. Left thighs of both groups were left untreated following subdermal doxorubicin infiltration. Total area of necrosis, as well as resultant epidermal thicknesses were assessed. Histological analyses were conducted using modified Verhofstad scoring system for comparison. Results Mean necrotic area was significantly smaller in the fat injection group compared to other groups. Median Verhofstad score was lesser in the fat injection group as well. Median epidermal thickness, on the other hand, was greater in the fat injection group. Conclusion Injection of fat grafts following vesicant extravasation might be beneficial in preventing the progression of tissue damage, if employed early.http://dx.doi.org/10.1080/08941939.2021.1966142extravasationfat injectionregenerative medicinechemotherapeuticsiatrogenic injury |
| spellingShingle | Ahmet Bicer Burak Sercan Ercin Tahir Gürler Gürkan Yiğittürk Yigit Uyanikgil Emel Oyku Cetin Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats Journal of Investigative Surgery extravasation fat injection regenerative medicine chemotherapeutics iatrogenic injury |
| title | Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats |
| title_full | Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats |
| title_fullStr | Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats |
| title_full_unstemmed | Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats |
| title_short | Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats |
| title_sort | possibility of taking an offensive stance in extravasation injury effects of fat injection in vesicant doxorubicin induced skin necrosis model in rats |
| topic | extravasation fat injection regenerative medicine chemotherapeutics iatrogenic injury |
| url | http://dx.doi.org/10.1080/08941939.2021.1966142 |
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