Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan
Dementia and cognitive impairment are considered to be one of the biggest social and medical problems. While there is a definite relationship between vitamin B and cognitive decline, this has yet to be fully assessed with regard to sex differences. Thus, the present study investigated the relationsh...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.667215/full |
| _version_ | 1818411260334571520 |
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| author | Ayako Miki Ayako Miki Ryuta Kinno Hirotaka Ochiai Satomi Kubota Yukiko Mori Akinori Futamura Azusa Sugimoto Takeshi Kuroda Hideyo Kasai Satoshi Yano Sotaro Hieda Akatsuki Kokaze Kenjiro Ono |
| author_facet | Ayako Miki Ayako Miki Ryuta Kinno Hirotaka Ochiai Satomi Kubota Yukiko Mori Akinori Futamura Azusa Sugimoto Takeshi Kuroda Hideyo Kasai Satoshi Yano Sotaro Hieda Akatsuki Kokaze Kenjiro Ono |
| author_sort | Ayako Miki |
| collection | DOAJ |
| description | Dementia and cognitive impairment are considered to be one of the biggest social and medical problems. While there is a definite relationship between vitamin B and cognitive decline, this has yet to be fully assessed with regard to sex differences. Thus, the present study investigated the relationship of vitamin B1 or vitamin B12 with dementia in accordance with the sex in 188 patients who visited the Memory Clinic at Showa University Hospital in Japan from March 2016 to March 2019. Cognitive function was tested by the Japanese version of the Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-Revised (HDS-R). Blood tests were performed to measure the vitamin levels. Logistic regression analysis was used to calculate the odds ratio (OR) for dementia and the 95% confidence interval (CI). Compared to the highest vitamin group (third tertile), the lowest vitamin group (first tertile) exhibited a significantly increased OR for dementia defined by MMSE for vitamin B1 (OR:3.73, 95% CI:1.52–9.16) and vitamin B12 (2.97, 1.22–7.28) among women. In contrast, vitamin levels were not significantly associated with dementia determined by MMSE in men. These findings were similar even when dementia was defined by HDS-R. The present study suggests that vitamin B1 plays a role in preventing development of dementia in women. Future longitudinal studies will need to be undertaken in order to examine whether decreasing vitamin levels occur before or after cognitive impairment, and whether maintaining a higher vitamin level can prevent a worsening of cognitive function and the development of dementia. |
| first_indexed | 2024-12-14T10:28:35Z |
| format | Article |
| id | doaj.art-dbb5cc544bcf4c9b97872d4c12aba3ca |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-14T10:28:35Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-dbb5cc544bcf4c9b97872d4c12aba3ca2022-12-21T23:06:14ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-04-011310.3389/fnagi.2021.667215667215Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in JapanAyako Miki0Ayako Miki1Ryuta Kinno2Hirotaka Ochiai3Satomi Kubota4Yukiko Mori5Akinori Futamura6Azusa Sugimoto7Takeshi Kuroda8Hideyo Kasai9Satoshi Yano10Sotaro Hieda11Akatsuki Kokaze12Kenjiro Ono13Department of Hygiene, Public Health and Preventive Medicine, Showa University School of Medicine, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Hygiene, Public Health and Preventive Medicine, Showa University School of Medicine, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDepartment of Hygiene, Public Health and Preventive Medicine, Showa University School of Medicine, Tokyo, JapanDepartment of Neurology, School of Medicine, Showa University, Tokyo, JapanDementia and cognitive impairment are considered to be one of the biggest social and medical problems. While there is a definite relationship between vitamin B and cognitive decline, this has yet to be fully assessed with regard to sex differences. Thus, the present study investigated the relationship of vitamin B1 or vitamin B12 with dementia in accordance with the sex in 188 patients who visited the Memory Clinic at Showa University Hospital in Japan from March 2016 to March 2019. Cognitive function was tested by the Japanese version of the Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-Revised (HDS-R). Blood tests were performed to measure the vitamin levels. Logistic regression analysis was used to calculate the odds ratio (OR) for dementia and the 95% confidence interval (CI). Compared to the highest vitamin group (third tertile), the lowest vitamin group (first tertile) exhibited a significantly increased OR for dementia defined by MMSE for vitamin B1 (OR:3.73, 95% CI:1.52–9.16) and vitamin B12 (2.97, 1.22–7.28) among women. In contrast, vitamin levels were not significantly associated with dementia determined by MMSE in men. These findings were similar even when dementia was defined by HDS-R. The present study suggests that vitamin B1 plays a role in preventing development of dementia in women. Future longitudinal studies will need to be undertaken in order to examine whether decreasing vitamin levels occur before or after cognitive impairment, and whether maintaining a higher vitamin level can prevent a worsening of cognitive function and the development of dementia.https://www.frontiersin.org/articles/10.3389/fnagi.2021.667215/fulldementiacognitive impairmentsex differencesvitamin B1 (thiamine)vitamin B12 (cobalamin)memory clinic outpatients |
| spellingShingle | Ayako Miki Ayako Miki Ryuta Kinno Hirotaka Ochiai Satomi Kubota Yukiko Mori Akinori Futamura Azusa Sugimoto Takeshi Kuroda Hideyo Kasai Satoshi Yano Sotaro Hieda Akatsuki Kokaze Kenjiro Ono Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan Frontiers in Aging Neuroscience dementia cognitive impairment sex differences vitamin B1 (thiamine) vitamin B12 (cobalamin) memory clinic outpatients |
| title | Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan |
| title_full | Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan |
| title_fullStr | Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan |
| title_full_unstemmed | Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan |
| title_short | Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan |
| title_sort | sex differences in the relationship of serum vitamin b1 and b12 to dementia among memory clinic outpatients in japan |
| topic | dementia cognitive impairment sex differences vitamin B1 (thiamine) vitamin B12 (cobalamin) memory clinic outpatients |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.667215/full |
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