Intrathoracic neurogenic tumors (ITNs): Management of solid and cystic lesions
Abstract Background Intrathoracic neurogenic tumors (INTs) are derived from nerve tissue and grow within the chest. Preoperative diagnosis can be challenging and only complete surgical exeresis enables confirmation of the suspected diagnosis. Here, we analyzed our experience on management of paraver...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14927 |
| _version_ | 1827909466232717312 |
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| author | Giovanni Natale Stefano Forte Gaetana Messina Beatrice Leonardi Rosa Mirra Francesco Leone Vincenzo Di Filippo Davide Gerardo Pica Francesca Capasso Mary Bove Antonio Noro Giorgia Opromolla Mario Martone Sabrina De Angelis Alfonso Fiorelli |
| author_facet | Giovanni Natale Stefano Forte Gaetana Messina Beatrice Leonardi Rosa Mirra Francesco Leone Vincenzo Di Filippo Davide Gerardo Pica Francesca Capasso Mary Bove Antonio Noro Giorgia Opromolla Mario Martone Sabrina De Angelis Alfonso Fiorelli |
| author_sort | Giovanni Natale |
| collection | DOAJ |
| description | Abstract Background Intrathoracic neurogenic tumors (INTs) are derived from nerve tissue and grow within the chest. Preoperative diagnosis can be challenging and only complete surgical exeresis enables confirmation of the suspected diagnosis. Here, we analyzed our experience on management of paravertebral lesions with solid and cystic patterns. Methods A monocentric retrospective study was conducted, which included 25 consecutive cases of ITNs in the period from 2010 to 2022. These cases had been surgically treated by thoracoscopic resection alone, or in combination with neurosurgery in the case of dumbbell tumors. The demographic and operative data along with complications were recorded and analyzed. Results Twenty‐five patients were diagnosed with a paravertebral lesion of which 19 (76%) had solid features and six (24%) had cystic features. The most common diagnosis was schwannoma (72%), followed by neurofibroma (20%) and malignant schwannoma (8%). In four cases (12%) the tumor showed an intraspinal extension. None of the patients had recurrence until 6 months of follow‐up. Comparison between the VATS and thoracotomy procedures showed that outcome of discharge on the postoperative day, on average, was 2.61 ± 0.5 versus 3.51 ± 0.53, respectively (p‐value <0.001). Conclusion The treatment of choice for INTs is complete resection which is tailored to tumor size, location, and extension. In our study, paravertebral tumors with cystic characteristics were not associated with an intraspinal extension and did not show a different behavior from solid tumors. |
| first_indexed | 2024-03-13T01:38:14Z |
| format | Article |
| id | doaj.art-dbb6989a53684455a049b334a049564c |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-03-13T01:38:14Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-dbb6989a53684455a049b334a049564c2023-07-04T00:04:27ZengWileyThoracic Cancer1759-77061759-77142023-07-0114191824183010.1111/1759-7714.14927Intrathoracic neurogenic tumors (ITNs): Management of solid and cystic lesionsGiovanni Natale0Stefano Forte1Gaetana Messina2Beatrice Leonardi3Rosa Mirra4Francesco Leone5Vincenzo Di Filippo6Davide Gerardo Pica7Francesca Capasso8Mary Bove9Antonio Noro10Giorgia Opromolla11Mario Martone12Sabrina De Angelis13Alfonso Fiorelli14Department of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyGenomics and Experimental Oncology Unit IOM Ricerca Viagrande ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyDepartment of Translation Medicine, Thoracic Surgery Unit Università della Campania “Luigi Vanvitelli” Naples ItalyAbstract Background Intrathoracic neurogenic tumors (INTs) are derived from nerve tissue and grow within the chest. Preoperative diagnosis can be challenging and only complete surgical exeresis enables confirmation of the suspected diagnosis. Here, we analyzed our experience on management of paravertebral lesions with solid and cystic patterns. Methods A monocentric retrospective study was conducted, which included 25 consecutive cases of ITNs in the period from 2010 to 2022. These cases had been surgically treated by thoracoscopic resection alone, or in combination with neurosurgery in the case of dumbbell tumors. The demographic and operative data along with complications were recorded and analyzed. Results Twenty‐five patients were diagnosed with a paravertebral lesion of which 19 (76%) had solid features and six (24%) had cystic features. The most common diagnosis was schwannoma (72%), followed by neurofibroma (20%) and malignant schwannoma (8%). In four cases (12%) the tumor showed an intraspinal extension. None of the patients had recurrence until 6 months of follow‐up. Comparison between the VATS and thoracotomy procedures showed that outcome of discharge on the postoperative day, on average, was 2.61 ± 0.5 versus 3.51 ± 0.53, respectively (p‐value <0.001). Conclusion The treatment of choice for INTs is complete resection which is tailored to tumor size, location, and extension. In our study, paravertebral tumors with cystic characteristics were not associated with an intraspinal extension and did not show a different behavior from solid tumors.https://doi.org/10.1111/1759-7714.14927ITNsneurogenic tumorsschwannomaparavertebral tumors |
| spellingShingle | Giovanni Natale Stefano Forte Gaetana Messina Beatrice Leonardi Rosa Mirra Francesco Leone Vincenzo Di Filippo Davide Gerardo Pica Francesca Capasso Mary Bove Antonio Noro Giorgia Opromolla Mario Martone Sabrina De Angelis Alfonso Fiorelli Intrathoracic neurogenic tumors (ITNs): Management of solid and cystic lesions Thoracic Cancer ITNs neurogenic tumors schwannoma paravertebral tumors |
| title | Intrathoracic neurogenic tumors (ITNs): Management of solid and cystic lesions |
| title_full | Intrathoracic neurogenic tumors (ITNs): Management of solid and cystic lesions |
| title_fullStr | Intrathoracic neurogenic tumors (ITNs): Management of solid and cystic lesions |
| title_full_unstemmed | Intrathoracic neurogenic tumors (ITNs): Management of solid and cystic lesions |
| title_short | Intrathoracic neurogenic tumors (ITNs): Management of solid and cystic lesions |
| title_sort | intrathoracic neurogenic tumors itns management of solid and cystic lesions |
| topic | ITNs neurogenic tumors schwannoma paravertebral tumors |
| url | https://doi.org/10.1111/1759-7714.14927 |
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