Roles of Stress Response in Autophagy Processes and Aging-Related Diseases
The heat shock factor 1 (HSF1)-mediated stress response pathway and autophagy processes play important roles in the maintenance of proteostasis. Autophagy processes are subdivided into three subtypes: macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy. Recently, molecular chapero...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/13804 |
| _version_ | 1797579757540343808 |
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| author | Yoshihisa Watanabe Katsutoshi Taguchi Masaki Tanaka |
| author_facet | Yoshihisa Watanabe Katsutoshi Taguchi Masaki Tanaka |
| author_sort | Yoshihisa Watanabe |
| collection | DOAJ |
| description | The heat shock factor 1 (HSF1)-mediated stress response pathway and autophagy processes play important roles in the maintenance of proteostasis. Autophagy processes are subdivided into three subtypes: macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy. Recently, molecular chaperones and co-factors were shown to be involved in the selective degradation of substrates by these three autophagy processes. This evidence suggests that autophagy processes are regulated in a coordinated manner by the HSF1-mediated stress response pathway. Recently, various studies have demonstrated that proteostasis pathways including HSF1 and autophagy are implicated in longevity. Furthermore, they serve as therapeutic targets for aging-related diseases such as cancer and neurodegenerative diseases. In the future, these studies will underpin the development of therapies against various diseases. |
| first_indexed | 2024-03-10T22:41:38Z |
| format | Article |
| id | doaj.art-dbb6de3103dc48a3a91928266675a0cb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:41:38Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dbb6de3103dc48a3a91928266675a0cb2023-11-19T11:03:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181380410.3390/ijms241813804Roles of Stress Response in Autophagy Processes and Aging-Related DiseasesYoshihisa Watanabe0Katsutoshi Taguchi1Masaki Tanaka2Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto 602-8566, JapanDepartment of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 601-0841, JapanDepartment of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 601-0841, JapanThe heat shock factor 1 (HSF1)-mediated stress response pathway and autophagy processes play important roles in the maintenance of proteostasis. Autophagy processes are subdivided into three subtypes: macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy. Recently, molecular chaperones and co-factors were shown to be involved in the selective degradation of substrates by these three autophagy processes. This evidence suggests that autophagy processes are regulated in a coordinated manner by the HSF1-mediated stress response pathway. Recently, various studies have demonstrated that proteostasis pathways including HSF1 and autophagy are implicated in longevity. Furthermore, they serve as therapeutic targets for aging-related diseases such as cancer and neurodegenerative diseases. In the future, these studies will underpin the development of therapies against various diseases.https://www.mdpi.com/1422-0067/24/18/13804macroautophagychaperone-mediated autophagymicroautophagystress responseproteostasis networkaging |
| spellingShingle | Yoshihisa Watanabe Katsutoshi Taguchi Masaki Tanaka Roles of Stress Response in Autophagy Processes and Aging-Related Diseases International Journal of Molecular Sciences macroautophagy chaperone-mediated autophagy microautophagy stress response proteostasis network aging |
| title | Roles of Stress Response in Autophagy Processes and Aging-Related Diseases |
| title_full | Roles of Stress Response in Autophagy Processes and Aging-Related Diseases |
| title_fullStr | Roles of Stress Response in Autophagy Processes and Aging-Related Diseases |
| title_full_unstemmed | Roles of Stress Response in Autophagy Processes and Aging-Related Diseases |
| title_short | Roles of Stress Response in Autophagy Processes and Aging-Related Diseases |
| title_sort | roles of stress response in autophagy processes and aging related diseases |
| topic | macroautophagy chaperone-mediated autophagy microautophagy stress response proteostasis network aging |
| url | https://www.mdpi.com/1422-0067/24/18/13804 |
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