Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension

Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension

The aim of the study was to clarify the role of the interplay between hypertension and the renin-angiotensin system (RAS) in the pathophysiology of myocardial ischemia/reperfusion (I/R) injury. We hypothesized that in the late phase of hypertension with already developed signs of end-organ damage, i...

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Bibliographic Details
Main Authors: Zuzana Husková, Soňa Kikerlová, Matúš Miklovič, Petr Kala, František Papoušek, Jan Neckář
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Physiology
Subjects:
renin-angiotensin system
ischemia/reperfusion injury
ANG II-dependent hypertension
AT1 receptor antagonist
P-V analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1151308/full

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