Retinol-binding protein-4 and nonalcoholic fatty liver disease
Abstract. Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly common as the global economy grows and living standards improve. Timely and effective preventions and treatments for NAFLD are urgently needed. Retinol-binding protein-4 (RBP4), the protein that transports retinol through th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2022-05-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002135 |
| _version_ | 1828452479349555200 |
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| author | Hangkai Huang Chengfu Xu Yuanyuan Ji |
| author_facet | Hangkai Huang Chengfu Xu Yuanyuan Ji |
| author_sort | Hangkai Huang |
| collection | DOAJ |
| description | Abstract. Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly common as the global economy grows and living standards improve. Timely and effective preventions and treatments for NAFLD are urgently needed. Retinol-binding protein-4 (RBP4), the protein that transports retinol through the circulation, was found to be positively related to diabetes, obesity, cardiovascular disease, and other metabolic diseases. Observational studies on the association between serum RBP4 level and the prevalence of NAFLD found contradictory results. Some of the underlying mechanisms responsible for this association have been revealed, and the possible clinical implications of treating NAFLD by targeting RBP4 have been demonstrated. Future studies should focus on the predictive value of RBP4 on NAFLD development and its potential as a therapeutic target in NAFLD. |
| first_indexed | 2024-12-10T23:53:29Z |
| format | Article |
| id | doaj.art-dbb92237a732461889582d3037b1fc70 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-12-10T23:53:29Z |
| publishDate | 2022-05-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-dbb92237a732461889582d3037b1fc702022-12-22T01:28:40ZengWolters KluwerChinese Medical Journal0366-69992542-56412022-05-01135101182118910.1097/CM9.0000000000002135202205200-00007Retinol-binding protein-4 and nonalcoholic fatty liver diseaseHangkai Huang0Chengfu Xu1Yuanyuan Ji2Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.Abstract. Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly common as the global economy grows and living standards improve. Timely and effective preventions and treatments for NAFLD are urgently needed. Retinol-binding protein-4 (RBP4), the protein that transports retinol through the circulation, was found to be positively related to diabetes, obesity, cardiovascular disease, and other metabolic diseases. Observational studies on the association between serum RBP4 level and the prevalence of NAFLD found contradictory results. Some of the underlying mechanisms responsible for this association have been revealed, and the possible clinical implications of treating NAFLD by targeting RBP4 have been demonstrated. Future studies should focus on the predictive value of RBP4 on NAFLD development and its potential as a therapeutic target in NAFLD.http://journals.lww.com/10.1097/CM9.0000000000002135 |
| spellingShingle | Hangkai Huang Chengfu Xu Yuanyuan Ji Retinol-binding protein-4 and nonalcoholic fatty liver disease Chinese Medical Journal |
| title | Retinol-binding protein-4 and nonalcoholic fatty liver disease |
| title_full | Retinol-binding protein-4 and nonalcoholic fatty liver disease |
| title_fullStr | Retinol-binding protein-4 and nonalcoholic fatty liver disease |
| title_full_unstemmed | Retinol-binding protein-4 and nonalcoholic fatty liver disease |
| title_short | Retinol-binding protein-4 and nonalcoholic fatty liver disease |
| title_sort | retinol binding protein 4 and nonalcoholic fatty liver disease |
| url | http://journals.lww.com/10.1097/CM9.0000000000002135 |
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